Can I take Lansoprazole and Ibuprofen together?

Why this happens

Ibuprofen (an NSAID) inhibits prostaglandins that protect the stomach lining. Lansoprazole (a proton pump inhibitor) reduces the production of gastric acid, which lowers the risk of stomach irritation or ulcers caused by the ibuprofen.

What you should do

It is safe to take these together. In fact, if you are taking ibuprofen long-term, your doctor may have prescribed lansoprazole specifically to protect your stomach. Always take ibuprofen with food to further reduce the risk of indigestion.

Important precautions

Asthma

Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Stomach ulcers or bleeding

Avoid this medicine if you have a history of stomach ulcers or intestinal bleeding. Even with lansoprazole, ibuprofen significantly increases the risk of serious internal bleeding.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 20 weeks pregnant, as it can cause serious heart and kidney problems in the unborn baby and reduce amniotic fluid levels.

Food and drink warnings

Alcohol

Drinking alcohol while taking these medicines can increase the risk of stomach irritation and gastric bleeding. Lansoprazole is often prescribed to protect the stomach, but alcohol can counteract this by increasing stomach acid production.

Caffeine (Coffee, Tea, Energy Drinks)

Caffeine can increase the production of stomach acid. This may reduce the effectiveness of lansoprazole in treating conditions like acid reflux or stomach ulcers, and may worsen the stomach-irritating effects of ibuprofen.

Using other medicines?

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.