Skip to main content

Can I take Levothyroxine and Coffee together?

Drug interaction guide

Drinking coffee at the same time as taking levothyroxine can significantly reduce the amount of medicine your body absorbs. This means your thyroid hormone levels may stay too low, and your symptoms (like tiredness or feeling cold) might not improve as they should.

Continue reading below

Why this happens

Levothyroxine is a sensitive medicine that needs a very specific environment in the stomach to be absorbed properly. Coffee contains compounds that can bind to the medicine or change how quickly it moves through your digestive system, preventing it from entering your bloodstream effectively.

What you should do

You should take your levothyroxine on an empty stomach with a glass of plain water. Wait at least 30 to 60 minutes after taking your tablet before drinking coffee or eating breakfast. To ensure your dose works consistently, try to keep your routine the same every day.

Continue reading below

Important precautions

Coffee consumption timing

You must wait at least 30 to 60 minutes after taking levothyroxine before drinking coffee. Coffee significantly reduces the absorption of the medicine, which can lead to unstable thyroid levels.

Food and drink warnings

Coffee and Caffeine

Coffee can significantly reduce the amount of levothyroxine your body absorbs. You should wait at least 30 to 60 minutes after taking your levothyroxine before drinking coffee or tea.

Dairy products (Milk, Yoghurt, Cheese)

Calcium found in dairy products can interfere with the absorption of levothyroxine. It is best to take your medication on an empty stomach and wait at least 30 to 60 minutes before consuming dairy.

Soya products

Soya can interfere with how levothyroxine is absorbed. If you eat a lot of soya, your doctor may need to monitor your hormone levels more closely.

Papaya

There is some evidence that eating large amounts of papaya may reduce the absorption of levothyroxine.

High-fibre foods

A very high-fibre diet (such as large amounts of bran or beans) can reduce the absorption of levothyroxine. If you significantly change your fibre intake, inform your doctor.

Continue reading below

Using other medicines?

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.