Can I take Levothyroxine and Coffee together?
Drug interaction guide
Originally published 24 Jan 2026
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Drinking coffee at the same time as taking levothyroxine can significantly reduce the amount of medicine your body absorbs. This means your thyroid hormone levels may stay too low, and your symptoms (like tiredness or feeling cold) might not improve as they should.
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Why this happens
Levothyroxine is a sensitive medicine that needs a very specific environment in the stomach to be absorbed properly. Coffee contains compounds that can bind to the medicine or change how quickly it moves through your digestive system, preventing it from entering your bloodstream effectively.
What you should do
You should take your levothyroxine on an empty stomach with a glass of plain water. Wait at least 30 to 60 minutes after taking your tablet before drinking coffee or eating breakfast. To ensure your dose works consistently, try to keep your routine the same every day.
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Important precautions
Coffee consumption timing
You must wait at least 30 to 60 minutes after taking levothyroxine before drinking coffee. Coffee significantly reduces the absorption of the medicine, which can lead to unstable thyroid levels.
Food and drink warnings
Coffee and Caffeine
Coffee can significantly reduce the amount of levothyroxine your body absorbs. You should wait at least 30 to 60 minutes after taking your levothyroxine before drinking coffee or tea.
Dairy products (Milk, Yoghurt, Cheese)
Calcium found in dairy products can interfere with the absorption of levothyroxine. It is best to take your medication on an empty stomach and wait at least 30 to 60 minutes before consuming dairy.
Soya products
Soya can interfere with how levothyroxine is absorbed. If you eat a lot of soya, your doctor may need to monitor your hormone levels more closely.
Papaya
There is some evidence that eating large amounts of papaya may reduce the absorption of levothyroxine.
High-fibre foods
A very high-fibre diet (such as large amounts of bran or beans) can reduce the absorption of levothyroxine. If you significantly change your fibre intake, inform your doctor.
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Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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