Can I take Morphine and Paracetamol together?

Why this happens

Paracetamol and morphine have different 'mechanisms of action' (the way they work in the body). Paracetamol works mainly in the central nervous system to reduce pain signals, while morphine attaches to specific 'opioid receptors' to block pain. Because they don't interfere with each other's absorption or breakdown in the liver, they can be used safely at the same time.

What you should do

You can safely take paracetamol and morphine together as prescribed by your doctor. Always ensure you do not exceed the maximum dose of paracetamol (usually 4000mg or eight 500mg tablets in 24 hours) and follow the specific instructions for your morphine dosage. If you are taking a 'co-compound' medicine (like Co-codamol), check if it already contains paracetamol before taking extra.

Important precautions

Asthma or breathing problems

Morphine can cause life-threatening breathing difficulties; do not take it if you have severe asthma or chronic obstructive pulmonary disease (COPD).

Liver disease or high alcohol intake

Taking more than the recommended dose, or taking it while drinking heavily, can cause fatal liver failure. Never take more than one product containing paracetamol at a time.

Opioid use with alcohol or sedatives

Mixing morphine with alcohol or benzodiazepines (sleeping pills) is extremely dangerous and can lead to fatal respiratory arrest or coma.

Food and drink warnings

Alcohol

You must not drink alcohol while taking morphine. Alcohol can dangerously increase the sedative effects of morphine, leading to extreme sleepiness, breathing difficulties, and a potentially fatal overdose. Some long-acting morphine capsules can also release the entire dose at once into your system if taken with alcohol (known as 'dose dumping').

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.