Can I take Ozempic and Metformin together?

Why this happens

Both drugs work in different ways to lower blood glucose: metformin reduces the amount of sugar your liver produces, while Ozempic mimics a hormone that tells your pancreas to release insulin when you eat. Together, they have an 'additive' effect, meaning they work more powerfully than either drug alone. Additionally, Ozempic slows down how quickly your stomach empties, which can sometimes change how other medicines are absorbed, though this rarely affects metformin significantly.

What you should do

You should continue taking your medication as prescribed, but be aware of the signs of low blood sugar (such as feeling shaky, sweaty, dizzy, or hungry). It is a good idea to monitor your blood sugar levels more frequently when you first start Ozempic or change your dose. If you experience severe or persistent nausea or vomiting, speak to your doctor. Always carry a fast-acting glucose source (like glucose tablets or a sugary drink) just in case.

Important precautions

Pancreatitis

Stop using this medicine and seek immediate medical help if you develop severe, persistent stomach pain which may reach through to your back. This can be a sign of an inflamed pancreas.

Lactic Acidosis

This medicine can cause a rare but serious build-up of acid in the blood. You must stop taking it and seek urgent medical care if you experience extreme tiredness, breathing difficulties, or severe vomiting and diarrhoea, especially if you are dehydrated or drink heavy amounts of alcohol.

Diabetic Retinopathy

If you have a history of diabetic eye disease, you must inform your doctor. Rapid improvements in blood sugar can cause a temporary worsening of diabetic retinopathy, requiring close monitoring.

Food and drink warnings

Alcohol

Drinking alcohol while taking metformin can increase the risk of a rare but serious condition called lactic acidosis. It can also increase the risk of low blood sugar (hypoglycaemia). You should avoid excessive alcohol consumption and binge drinking.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.