Can I take Paracetamol and Amoxicillin together?

Why this happens

Paracetamol and amoxicillin are processed by the body in different ways. Paracetamol is primarily broken down by the liver, while amoxicillin is mainly cleared through the kidneys. They do not interfere with each other's absorption, metabolism, or effectiveness.

What you should do

You can take paracetamol and amoxicillin at the same time if needed. Always follow the dosage instructions on the packet or those provided by your doctor or pharmacist. If you are taking amoxicillin for an infection, make sure you finish the entire course even if you start to feel better.

Important precautions

Liver disease

You must not exceed the maximum dose of 4g (eight 500mg tablets) in 24 hours. Taking even a small amount more than the recommended dose can cause serious, permanent liver damage. Check all other medicines (like cold and flu remedies) to ensure they do not also contain paracetamol.

Penicillin allergy

Do not take this medicine if you have ever had an allergic reaction to penicillin or cephalosporin antibiotics. A reaction can be life-threatening.

Food and drink warnings

Alcohol

While a small amount of alcohol is generally considered safe, you should avoid drinking large amounts of alcohol (heavy drinking) while taking paracetamol. Chronic heavy drinking increases the risk of serious liver damage if you take paracetamol, even at recommended doses.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.