Can I take Simvastatin and Amlodipine together?

Why this happens

Amlodipine interferes with a specific enzyme in your liver (CYP3A4) that is responsible for breaking down simvastatin. Because the liver cannot clear the simvastatin as quickly as usual, the levels of the drug build up in your body.

What you should do

If you are taking both medicines, the dose of simvastatin should usually not exceed 20mg per day. If you are currently taking a higher dose (such as 40mg or 80mg), you must speak to your doctor about adjusting your prescription. Seek medical advice immediately if you experience unexplained muscle pain, tenderness, or weakness while taking this combination.

Important precautions

Pregnancy

You must not take simvastatin if you are pregnant or planning to become pregnant, as it may harm the developing baby. Use effective contraception while taking this medicine.

Grapefruit consumption

Avoid drinking large amounts of grapefruit juice. Grapefruit increases the level of these medicines in your blood, which significantly raises your risk of serious side effects like muscle damage.

Muscle pain or weakness

Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of these medicines in your blood, which makes side effects more likely. For simvastatin, you should avoid grapefruit juice completely. For amlodipine, you should avoid drinking large amounts of it.

Alcohol

Drinking large amounts of alcohol while taking simvastatin can increase your risk of liver problems and muscle side effects. It is best to keep your intake within the recommended low-risk limits.

Using other medicines?

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.