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Immune Thrombocytopenia

sukhi73226 Suzy2010 Mr A P Davies 109 Users are discussing this topic

Immune thrombocytopenia (ITP) is an autoimmune disease affecting platelets. It can also be called immune thrombocytopenic purpura. It used to be called "idiopathic thrombocytopenic purpura" but this is now an outdated term. 

Many people have no symptoms. If symptoms occur they can range from mild bruising to severe bleeding. In children the condition usually goes away on its own, without any treatment. In adults it is usually a lifelong condition. Treatment may or may not be necessary and may include steroids, immunoglobulin and surgery.

Platelets are tiny components of the blood which help blood to clot when we injure ourselves. They are also known as thrombocytes. They are made inside bone, in the bone marrow. They are released into the bloodstream and travel through the body for about seven days, before they are removed by the spleen. The spleen is an organ that lies at the top of the tummy (abdomen) under the ribs on the left-hand side.


A normal number of platelets is between 150 and 400 x 109 per litre. This is found by a blood test. If you have too many platelets, your blood will clot too easily. If you do not have enough platelets, you may bruise and bleed more easily than usual.

Immune thrombocytopenia (ITP) is an autoimmune disease involving platelets. In autoimmune disorders your body makes proteins called antibodies which damage another part of your body. In ITP the antibodies are made against platelets. Once the antibodies have attached to platelets, the platelets do not work so well. They are also removed more quickly by the spleen because they are abnormal.

  • It used to be called "idiopathic thrombocytopenic purpura." Idiopathic means that there is no known underlying cause found. Nowadays the word "immune" has replaced the word "idiopathic" because it is known that the immune system is the cause.
  • Thrombocytopenia or thrombocytopenic means not enough platelets.
  • Purpura is a purple-red rash. It is caused by tiny bleeds under the skin.

ITP is quite different in children and adults and should be considered separately.

ITP occurs in about 2 to 5 of every 100,000 children. It is most common in children around the age of 5 or 6, but it can occur at any age.

  • Most children will not have any symptoms.
  • Those who do develop symptoms have bruising or a purple or red rash - purpura. There may be tiny red spots, or larger areas of bruising or rash. This usually appears over 1-2 days.
  • Some have nosebleeds. Older girls may have heavier periods.
  • The condition often occurs about 2-3 weeks after an infection (often a common viral infection). Occasionally, it follows immunisation. The symptoms often disappear over 6-8 weeks, and by 6 months in most cases.
  • Very occasionally, it causes severe bleeding which requires emergency treatment.
  • The platelet levels in about 1 or 2 in 10 affected children do not return to normal after a year. This is then called chronic ITP, which means it is persistent. However, many of these children will never need any treatment.

So, what seems to happen in children with ITP is that the immune system is triggered to produce antibodies against the platelets by an infecting virus or other germ. In most cases, this is a temporary immune reaction that lasts several weeks only, and then symptoms go. But, in a few cases, the immune system continues to be faulty and the condition becomes long-standing.

ITP is diagnosed by a blood test called a full blood count. This test shows that there are fewer platelets than normal. The laboratory will also have a look at the blood under a microscope.

Sometimes different tests will be needed to make sure that the low number of platelets is not due to another of the possible causes. Rarely, this involves taking a sample of bone marrow. This is not needed if the blood count and symptoms are typical of ITP.

Most children will not need treatment, even if the number of platelets is very low. The decision to treat is usually based on whether your child has serious bleeding or very pronounced bruising and purpura. This is because some children can have very low platelet counts, but still not have any bleeding problems. If the symptoms are mild, usually there will be no need for treatment. Your child may need to have the full blood count repeated on a few occasions to check that the platelet numbers are stable and that the rest of the blood cell counts are remaining normal. If your child has bleeding and more severe bruising or purpura, treatment may be considered. The aim of treatment is to improve symptoms and increase the number of platelets.

If treatment is needed then the decision on what treatment to use can be difficult. This is because there have not been many studies testing the treatments against each other. The options for treatment include:

  • Prednisolone. This is often the first type of treatment tried. It is a steroid medication and is taken as syrup or tablets. This may be given as a high dose over a short period of time (four days) or as a lower dose for a longer time (two weeks). Prednisolone has been shown to increase the number of platelets quickly in about 3 in 4 children with ITP.
  • Other steroid options. High-dose methylprednisolone or high-dose dexamethasone. These are other types of steroid medicines that have also been shown to be effective in differing degrees. These are less often used now than they used to be.
  • Intravenous immunoglobulin (IVIg). This is an injection of a protein into the bloodstream and has been shown to work well in about 8 in 10 children in increasing the number of platelets. It is not usually used as the first option because it involves an injection. It can also cause quite a lot of side-effects and is quite expensive. It may be used as an emergency treatment if your child has severe bleeding or needs surgery.
  • Anti-D immunoglobulin. This is another type of protein that is also effective and causes fewer side-effects than IVIg. It can only be given to children whose blood group is rhesus (RhD) positive.
  • Platelet transfusions. In a life-threatening situation your child may be given a transfusion of platelets at the same time as being treated with steroids and IVIg. This only helps to increase the number of platelets for a short time. The transfused platelets are also attacked by the antibody that the body has produced and are destroyed by the spleen.
  • Other medicines. A number of other medicines may be used. These are not routinely recommended, as not enough information is known yet about their use and side-effects. One such medicine is called rituximab. This is used more in adults than in children at the moment in the UK.
  • Surgery to remove the spleen (splenectomy). This is very rarely done in children with ITP. It is only really considered as an option if your child has life-threatening bleeding or severe chronic disease that is affecting their day-to-day functioning.

In chronic ITP, usually no treatment is needed but your child will need to have regular blood tests and specialist review. If they have an injury or are involved in an accident you will be advised to take them to your local hospital emergency department for review. If the disease is severe then the treatments outlined above may be considered.

Children with ITP may be advised to avoid contact sports. This is because they may get more bleeding than normal from minor injuries. PE teachers or those looking after a child with ITP should be aware. Children with ITP should not take medicines such as aspirin or ibuprofen, as these can also increase the risk of bleeding. You should contact a doctor urgently if your child has:

  • A nosebleed which will not stop despite pinching the nose after 30 minutes.
  • Prolonged bleeding from the gums.
  • Blood in the poo (stools) or urine.
  • A heavy blow to the head, especially if the child is unwell afterwards in any way.
  • Persistent or severe headache.
  • Sickness (vomiting).
  • Unexplained drowsiness.

ITP occurs in about 3 in 100,000 adults every year. It is more common in women than in men between the ares of 30 and 60 years. At other ages, it is just as common in men as it is in women.

In adults, ITP comes on gradually and does not usually follow a viral illness. It is not really known what causes the disease. The symptoms may vary a lot. You may have no symptoms, purpura, mild bruising or bleeding, or severe bleeding. Unlike ITP in children, most adults with ITP will continue to have a low number of platelets indefinitely. This is called chronic ITP.

Because most adults with ITP do not have any symptoms, ITP is usually diagnosed on a routine blood test that has been done for other reasons. The full blood count shows a lower number of platelets than normal. The laboratory will also look at your blood under a microscope.

Sometimes (if your symptoms are unusual) a sample from your bone marrow may be necessary. Low platelet numbers can be due to other causes such as medication, viral infections or other diseases. It may be necessary for you to have some additional tests to rule out these other conditions.

Most adults with ITP do not require active treatment, unless they have significant symptoms or need to undergo surgery for any reason, including dental work. It is important to have adequate platelet levels before surgery, in order to reduce the risk of severe bleeding during the operation.

If treatment is needed then the first treatment that tends to be used in an adult with ITP is usually steroids. Sometimes steroids are used along with injections of IVIg. Both of these treatments increase the platelet count in many people. Usually though, this improvement is only temporary and the platelet numbers return to a low level after a few weeks. Anti-D immunoglobulin can also be used in adults and has been shown to increase platelet numbers effectively.

Surgery to remove the spleen (splenectomy) is used more often in adults than in children. It is more likely to result in a longer-lasting normal number of platelets. About 2 in 3 people with ITP who have a splenectomy will have a normal number of platelets afterwards for at least five years. However, splenectomy is not without possible complications. As the spleen is responsible for fighting certain types of infection, people who have had their spleen removed are more at risk of some serious infections. For this reason, you will need to have some extra vaccinations and may be advised to take antibiotics every day. See separate leaflet called Preventing Infection after Splenectomy for more details.

If the above treatments do not work, there are several other options. For example, you may be given another trial of steroids or IVIg. Other treatments that may be used include danazol and medications to suppress the immune system, such as azathioprine or ciclosporin. A medicine called rituximab has also produced good responses. Other new treatments include medicines which help you make more platelets. These are called romiplostim and eltrombopag. They may be used if you are having severe bleeding, and if other treatments have not been helpful.

A low number of platelets in pregnancy is quite common. It can be difficult to know if your platelet count is low due to the pregnancy or due to ITP. If you have no symptoms and the number of platelets is not too low, you may just be monitored.

If the number of platelets needs to be increased then steroids or IVIg can be used. ITP will not make a difference to which type of delivery you have.

It is very unlikely that your low number of platelets will cause any problems to your newborn baby. After they have been born, their platelet level will be checked and, if it is low, they will be monitored carefully. If they need treatment, IVIg can be used.

In adults, the outcome is variable depending on the severity of symptoms. Most people do not need any treatment. If treatment is needed, the response to treatment varies from person to person.

Further help & information

Original Author:
Dr Tim Kenny
Current Version:
Peer Reviewer:
Dr Hannah Gronow
Document ID:
9213 (v3)
Last Checked:
Next Review:
The Information Standard - certified member
See also: Immune Thrombocytopenia written for professionals
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