Fingolimod capsules (Gilenya)

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Fingolimod is a treatment for relapsing-remitting multiple sclerosis (MS) in adults.

Take one (500 microgram) capsule a day.

Side-effects include a slow heart rate at first, an increased risk of infection, and eye problems.

Type of medicineAn immunomodulating medicine
Used forRelapsing-remitting multiple sclerosis (MS) in adults
Also calledGilenya®
Available asCapsules

Multiple sclerosis (MS) is a condition which affects the brain and spinal cord. The protective cover around nerves in the brain and spinal cord is damaged in people with MS, and this stops the nerves from working as they should. Most people with MS have the relapsing-remitting form of the disease where symptoms come and go in episodes. A 'relapse' occurs when an episode of symptoms develops. The symptoms last for a period of time and then ease, or 'remit'. Further relapses occur from time to time, with periods of remission in between.

Fingolimod works by interfering with your immune system, because it is believed that this is responsible for causing the damage to the nerves. Fingolimod reduces the access of certain white blood cells to the brain and spinal cord, and this reduces the number of relapses in some people.

Fingolimod does not cure MS, and it is not a suitable treatment for everyone. It will be prescribed for you by a specialist and your treatment will be closely monitored.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking fingolimod it is important that your doctor knows:

  • If you have a condition which affects your immune system.
  • If you have been told you have an irregular heart rhythm.
  • If you have a problem with the way your liver works.
  • If you have any problems with your lungs or breathing.
  • If you are currently unwell, or have an infection or a high temperature (fever).
  • If you have been told you have cancer.
  • If you are pregnant or breast-feeding.
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about fingolimod and will provide you with a full list of the side-effects which you may experience from taking it.
  • You will be asked to take your first dose of fingolimod in a clinic where you can be observed. This is because it can slow your heart rate at first, and your doctor will want to check for this.
  • Take fingolimod exactly as your doctor tells you to. Take one capsule a day. Try to take your doses at the same time of day each day, as this will help you to remember to take fingolimod regularly.
  • Swallow the capsule with a drink of water. You can take fingolimod before or after meals.
  • Your doctor will give you instructions in case you forget to take a dose. You must follow the directions your doctor gives to you, but as a guide, the usual recommendation is that if you have been taking fingolimod for less than a month and you miss a dose, you should speak with your doctor before you take the next dose.
  • Remember to keep all your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have regular blood tests and eye checks during the treatment.
  • If you are due to have any vaccinations, it is very important that the person treating you knows that you are taking this medicine. This is because fingolimod will make some vaccines less effective, and also because you will be at risk of getting an infection from some vaccines.
  • Women must avoid getting pregnant while taking fingolimod, and for at least two months afterwards. Make sure that you have discussed with your doctor which types of contraception are suitable for you and your partner.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with fingolimod. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common fingolimod side-effectsWhat can I do if I experience this?
Infections (in particular nose, throat and lung infections), coughSpeak with your doctor if troublesome
Feeling dizzy or tired, blurred visionDo not drive or use tools or machines while affected
Headache, back painAsk your doctor or pharmacist to recommend a suitable painkiller. If the headache is sudden or severe, speak with your doctor straightaway
DiarrhoeaDrink plenty of water
Low mood, skin problemsSpeak with your doctor if troublesome
Slow heart rate, changes to some blood test results, blood pressure changesYour doctor will check for these

If you experience any other symptoms which you think may be due to the capsules, speak with your doctor or pharmacist for further advice.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

If you buy any medicines, always check with your doctor or a pharmacist that they are suitable for you to take.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • Manufacturer's PIL, Gilenya® 0.5 mg hard capsules; Novartis Pharmaceuticals UK Ltd, The electronic Medicines Compendium. Dated June 2014.
  • British National Formulary; 68th Edition (Sep 2014) British Medical Association and Royal Pharmaceutical Society of Great Britain, London

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr John Cox
Document ID:
28960 (v1)
Last Checked:
Next Review:
The Information Standard - certified member

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