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Damage to the femoral nerve may result from trauma, iatrogenically, or as a consequence of disease processes. Disruption may be complete or partial.
Femoral nerve lesions are uncommon. One study of 27,004 primary hip arthroplasties found only two patients with complete and one with partial femoral nerve palsy.A review of cases treated surgically at a neurosurgical department found 119 patients over a period of 33 years. 52 cases were iatrogenic, 19 were due to hip or pelvic fractures, 10 to gunshot wounds and 8 to lacerations. The remainder were the result of various tumours or cysts.
- Hip arthroplasty.
- Abdominopelvic operations (particularly where self-retaining retractors are used).
- Compression or stretching during obstetric procedures.
- Pelvic surgery.
- Coronary angiography.
- Trauma - hip or pelvic fractures, thigh lacerations (these are often partial lesions, affecting nerve supply to the quadriceps).
- Psoas haematoma - can occur as a complication of anticoagulant therapy or in haemophilia.
- Psoas abscess.
- Diabetic amyotrophy (proximal neuropathy, seen in patients with diabetes, causes burning pain in the hip and thigh and wasting of thigh muscles).
- Tumours - a variety of benign and malignant tumours - eg:
- Arthropathy - femoral nerve palsy secondary to synovitis of the hip joint.
- Neonatal - femoral nerve palsy has been reported after breech lie in utero.
There may be instability of the knee (often described as 'buckling') on climbing stairs. The weakness is typically acute or subacute, in contrast to that caused by myopathy, in which the onset is often gradual and usually bilateral. Numbness of the medial side of the leg and calf may occur. Involvement of the lateral cutaneous branch of the nerve may produce painful paraesthesiae of the thigh (meralgia paraesthetica). Mild pain near the inguinal ligament may be experienced. Acute severe pain in the groin, thigh and lower abdomen may occur if the cause is a retroperitoneal haematoma.
These may include:
- Quadriceps muscle weakness and wasting.
- Loss of knee jerk.
- Numbness along the medial side of the thigh and anteromedial side of the calf (the L2-L4 dermatomes - see figures below).
- Pain on hip extension (in cases of retroperitoneal haematoma).
In one small study after gynaecological surgery, diagnosis was made based on the following criteria:
- History of falling during postoperative ambulation.
- Quadriceps weakness.
- Straight leg raise weakness.
- Diminished knee jerk response.
- No evidence of psoas haematoma or abscess.
- Diabetic neuropathy.
- Focal muscular atrophies
- HIV-1-associated multiple mononeuropathies.
- Inclusion body myositis (a group of hereditary disorders causing muscle weakness in which inclusion bodies are seen on microscopy of muscle cells).
- Leptomeningeal carcinomatosis.
- Metabolic myopathies.
- Polyarteritis nodosa.
- Systemic lupus erythematosus.
- Vasculitic neuropathy.
- Lumbar plexopathies (peripheral neuropathy in the area of the lumbar plexus).
- Lumbosacral disc syndromes.
A CT scan of the abdomen may help to exclude retroperitoneal haematoma if this is suspected. CT or MRI imaging of the pelvis may also help to elucidate the cause (eg, tumour or aneurysm).
- Nerve conduction studies may reveal motor deficit.
- Electromyography may show quadriceps weakness. Iliopsoas involvement may be demonstrated in pelvic lesions (ie above the inguinal ligament).
Most patients can be treated conservatively with exercises, avoidance of excessive external rotation and abduction of the hip and with knee bracing.
Medical treatment depends on the underlying cause and this may include chemotherapy for an underlying tumour, immunotherapy for a diabetic or vasculitic cause and neuropathic pain medication (eg, pregabalin, gabapentin, amitriptyline).
The successful use of permanent percutaneous femoral nerve stimulation using a stimulating lead placed close to the femoral nerve with the aid of ultrasound guidance has been reported.
Surgical procedures which may be required include:
- Drainage of a psoas haematoma or abscess.
- Treatment of a tumour.
- Surgical decompression of the nerve.
- Surgical exploration for other reasons (eg, penetrating wounds).
- Nerve grafting after tumour excision.
- Successful transfer of the obturator nerve to the femoral nerve has been reported.
Prognosis depends on the underlying cause. Most cases resolve spontaneously or with the aid of physical therapy. Symptoms caused by compression or stretching (eg, obstetric) can take three to four months to settle. Some patients are left with permanent residual neurological deficits.
Further reading and references
Kurt S, Kaplan Y, Karaer H, et al; Femoral nerve involvement in diabetics. Eur J Neurol. 2009 Mar16(3):375-9.
Retroperitoneal Hematoma with Femoral Nerve Damage; Nucleus Medical Media
Farrell CM, Springer BD, Haidukewych GJ, et al; Motor nerve palsy following primary total hip arthroplasty. J Bone Joint Surg Am. 2005 Dec87(12):2619-25.
Kim DH, Murovic JA, Tiel RL, et al; Intrapelvic and thigh-level femoral nerve lesions: management and outcomes in 119 surgically treated cases. J Neurosurg. 2004 Jun100(6):989-96.
Head KA; Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec11(4):294-329.
Pechter EA, Smith PB; Transient femoral neuropathy after abdominoplasty. Ann Plast Surg. 2008 Nov61(5):492-3.
Barcin C, Kursaklioglu H, Kose S, et al; Transient femoral nerve palsy after diagnostic coronary angiography. Anadolu Kardiyol Derg. 2009 Jun9(3):248-9.
Atkinson C, Morris SK, Ng V, et al; A child with fever, hip pain and limp. CMAJ. 2006 Mar 28174(7):924.
Idiculla J, Shirazi N, Opacka-Juffry J, et al; Diabetic amyotrophy: a brief review. Natl Med J India. 2004 Jul-Aug17(4):200-2.
Stuplich M, Hottinger AF, Stoupis C, et al; Combined femoral and obturator neuropathy caused by synovial cyst of the hip. Muscle Nerve. 2005 Oct32(4):552-4.
Tajima Y, Sudoh K, Matsumoto A, et al; Femoral neuropathy induced by a low-grade myofibroblastic sarcoma of the groin. J Neurol. 2005 Nov252(11):1416-7. Epub 2005 Jun 27.
Tatsumura M, Mishima H, Shiina I, et al; Femoral nerve palsy caused by a huge iliopectineal synovitis extending to the iliac fossa in a rheumatoid arthritis case. Mod Rheumatol. 200818(1):81-5. Epub 2008 Jan 5.
Szalay EA; Femoral nerve palsy and hip instability in infants with breech birth presentation: a review of the literature and report of 2 cases. J Pediatr Orthop. 2010 Oct-Nov30(7):739-41.
Felice KJ; Focal neuropathies of the femoral, obturator, lateral femoral cutaneous and other nerves of the thigh and pelvis. In: Bromberg MB, Smith GA,eds. Handbook of Peripheral Neuropathy. Boca Raton,FI: Taylor and Francis 2005: chapter 31.
Fanning J, Carol T, Miller D, et al; Postoperative femoral motor neuropathy: diagnosis and treatment without neurologic consultation or testing. J Reprod Med. 2007 Apr52(4):285-8.
Goyal N et al; Neuropathies - Weakness: Guidelines for a Cost-Effective Workup, ConsultantLive, 2007
Goyal N et al; Myopathies - Weakness: Guidelines for a Cost-Effective Workup, ConsultantLive, 2007
Ducic I, Dellon L, Larson EE; Treatment concepts for idiopathic and iatrogenic femoral nerve mononeuropathy. Ann Plast Surg. 2005 Oct55(4):397-401.
Narouze SN, Zakari A, Vydyanathan A; Ultrasound-guided placement of a permanent percutaneous femoral nerve stimulator leads for the treatment of intractable femoral neuropathy. Pain Physician. 2009 Jul-Aug12(4):E305-8.
Parmer SS, Carpenter JP, Fairman RM, et al; Femoral neuropathy following retroperitoneal hemorrhage: case series and review of the literature. Ann Vasc Surg. 2006 Jul20(4):536-40. Epub 2006 May 31.
Tsuchihara T, Nemoto K, Arino H, et al; Sural nerve grafting for long defects of the femoral nerve after resection of a retroperitoneal tumour. J Bone Joint Surg Br. 2008 Aug90(8):1097-100.
Campbell AA, Eckhauser FE, Belzberg A, et al; Obturator nerve transfer as an option for femoral nerve repair: case report. Neurosurgery. 2010 Jun66(6 Suppl Operative):375
Moore AE, Stringer MD; Iatrogenic femoral nerve injury: a systematic review. Surg Radiol Anat. 2011 Feb 17.
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