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Synonym: clostridial myonecrosis

This is a life-threatening bacterial infection with gangrene which has the following three features:

  • Muscle necrosis
  • Sepsis
  • Gas production - usually a mixture of hydrogen, carbon dioxide, nitrogen and oxygen

These can rapidly lead to septicaemia, septic shock and death.

Gas gangrene can be broadly grouped into:

Traumatic or surgical

Usually caused by direct inoculation with clostridia (especially Clostridium perfringens) but there are other causes too (see 'Pathogens', below).

Non-traumatic or spontaneous

  • More rare and most often caused by Clostridium septicum.
  • Seen in the setting of colonic neoplasms, immunosuppression or neutropenia.[1]
  • C. septicum from the gastrointestinal (GI) tract can pass via the blood to muscles (associated with a very poor prognosis). C. septicum is aerotolerant and can infect normal tissue.

The Clostridium species C. perfringens, C. septicum and C. histolyticum are the principal causes of trauma-associated gas gangrene and their incidence increases dramatically in times of war, hurricanes, earthquakes and other mass casualty conditions.[2]

The vast majority of cases are caused by clostridia, especially C. perfringens.

  • Clostridium spp. (found in soil and normal GI tract flora of humans and animals) - eg, C. perfringens, C. septicum, C. novyi , C. histolyticum
  • Bacteroides spp.
  • Anaerobic streptococci

The Infectious Disease Society of America has defined gas gangrene as an infection caused by Clostridium species. However soft tissue infections that produce subcutaneous gas have often been diagnosed as gas gangrene without identification of the presence of Clostridium species. The diagnosis has instead been based on clinical and radiological findings.[3]

In traumatic or surgical gas gangrene the pathogens enter through wounds, usually after contact with soil - eg, soil contaminated with faeces (not always so). The development of gas gangrene does not simply occur with the presence of Clostridium spp. - the environment has to have enough devitalised tissue present to support anaerobic metabolism.

The destruction caused by the pathogen is caused by the release of exotoxins. C. perfringens releases alpha toxin - which requires anaerobic surroundings to survive and thrive, and also theta toxin. This explains why hypoxic or poorly perfused tissue is attractive to these organisms.

The powerful toxins lead to breakdown of cells, coagulation and microvascular thrombosis and these can consequently add or contribute to rhabdomyolysis and acute kidney injury. The toxins also lead to haemolysis of red blood cells, cardiac depression and shock through vasodilatation.

Risk factors for gas gangrene

These include:

  • Chronic alcohol abuse.
  • Malnutrition.
  • Trauma (eg, burns, crush injuries, open fractures), and large muscle involvement (eg, thigh).
  • Diabetes mellitus.[4]
  • Corticosteroid use.
  • GI tract malignancy - eg, infection of perineum or scrotum from colonic seeding.
  • Haematological disease with immunosuppression.
  • Has been reported to follow intramuscular injections.[5]
  • Features relating to the wound - eg. contamination with dirt or shrapnel.
  • Abortion (especially criminal abortion). 

The incubation period varies from one to several days but symptoms may progress within hours.

  • Initially - no skin changes - just pain.
  • Systemic symptoms - eg, fever, dehydration.
  • Once nerves are damaged, anaesthesia occurs.
  • Paralysis.
  • Skin changes - cellulitic progressing to dark purple; vesicles and bullae develop.[6]
  • Subcutaneous air on palpation (may not be present early on).
  • Foul-smelling discharge.
  • Oedema.
  • Necrotic or haemorrhagic tissue.
  • Patients may also present in septicaemic shock with tachycardia, hypotension, fever, and stupor.

This includes:

  • FBC
  • Renal function
  • LFTs
  • Creatine kinase
  • Specimens from skin for culture - eg, vesicle exudate
  • Immunological methods - provide more rapid diagnosis
  • Blood cultures
  • Arterial blood gas - patients may be acidotic
  • Urine dipstick - query myoglobinuria
  • Plain X-rays - will show gas in soft tissues[6]

Gas gangrene is a rare and deadly infection that progresses very rapidly. Prompt diagnosis and treatment is therefore vital.[7]

  • Supportive therapy - for example, analgesia, oxygen, intravenous fluids and good nourishment.
  • Surgical - radical debridement of necrotic tissue (may require amputation if a limb is involved).
  • Antibiotics - these do not work alone, as they are unable to penetrate the necrotic tissue. Cover Gram-negative, Gram-positive and anaerobes - eg, combination of penicillin, gentamicin and metronidazole.
  • Hyperbaric oxygen therapy - kills anaerobic C. perfringens; however, efficacy has not been proven.[8]
  • Tetanus toxoid may also be indicated.[9]
  • Multi-organ failure
  • Spread to involve bone marrow[10]
  • Disseminated intravascular coagulation

Mortality rates for patients with gas gangrene from trauma or surgery are as high as 25%, but increase to 50-80% for patients injured in natural hazards. This can be improved with better and more rapid recognition of the disease followed by early treatment of gas gangrene.[11]

Further reading and references

  1. Ying Z, Zhang M, Yan S, et al; Gas gangrene in orthopaedic patients. Case Rep Orthop. 20132013:942076. doi: 10.1155/2013/942076. Epub 2013 Oct 28.

  2. Stevens DL, Aldape MJ, Bryant AE; Life-threatening clostridial infections. Anaerobe. 2012 Apr18(2):254-9. doi: 10.1016/j.anaerobe.2011.11.001. Epub 2011 Nov 20.

  3. Brucato MP, Patel K, Mgbako O; Diagnosis of Gas Gangrene: Does a Discrepancy Exist between the Published Data and Practice. J Foot Ankle Surg. 2013 Dec 14. pii: S1067-2516(13)00488-2. doi: 10.1053/j.jfas.2013.10.009.

  4. Chuhan FA; Non-traumatic clostridium infection: report of an unusual case with rapid progression and a paucity of clinical signs in a patient with type 1 diabetes. Emerg Med J. 2006 Nov23(11):e58.

  5. Rossitto M, Manfre A, Scalisi M, et al; Multiple treatment of gas gangrene at a rare anatomic location. Case report. Minerva Anestesiol. 2004 Mar70(3):125-9.

  6. Anesti E, Brooks P, Majumder S; Images in emergency medicine. Gas gangrene. Ann Emerg Med. 2007 Jul50(1):14, 33.

  7. Smith-Slatas CL, Bourque M, Salazar JC; Clostridium septicum infections in children: a case report and review of the literature. Pediatrics. 2006 Apr117(4):e796-805. Epub 2006 Mar 27.

  8. Wang C, Schwaitzberg S, Berliner E, et al; Hyperbaric oxygen for treating wounds: a systematic review of the literature. Arch Surg. 2003 Mar138(3):272-9

  9. Tetanus: guidance, data and analysis; Public Health England

  10. Janssen E, den Ouden H, van Herwaarden J, et al; Gas gangrene spreading to the bone marrow. Neth J Med. 2006 Jul-Aug64(7):256-7.

  11. Wang Y, Lu B, Hao P, et al; Comprehensive treatment for gas gangrene of the limbs in earthquakes. Chin Med J (Engl). 2013 Oct126(20):3833-9.