Lymphatic Filariasis

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Filariasis is a group of diseases that affect humans and animals. Human filarial infections include lymphatic filariasis, onchocerciasis, loaisis and mansonellosis. These infections are believed to affect almost 200 million individuals worldwide with the major burden in developing countries[1].

The agent is a nematode parasite of the order Filariidae, commonly called filariae. They are usually classified according to the final habitat of the adult worms in the human host.

  • The cutaneous group includes Loa loa, Onchocerca volvulus and Mansonella streptocerca.
  • The lymphatic group includes Wuchereria bancrofti, Brugia malayi and Brugia timori.
  • The body cavity group includes Mansonella perstans and Mansonella ozzardi.

The cutaneous and lymphatic groups are the most important.

There are hundreds of filarial parasites but only eight species cause infections in humans. A few other species can cause incomplete infection but they are unable to complete the life cycle in the human.

This article will explore lymphatic filariasis; see separate Body Cavity Filariasis, Cutaneous Filariasis and Nematodes (Roundworms) articles.

The life cycle, in common with all nematodes, has five developmental or larval stages in a vertebral host and an arthropod intermediate host and vector.

  • Adult female worms produce thousands of first-stage larvae or microfilariae that are ingested by a feeding insect vector.
  • The arthropod vectors are mosquitoes or flies. They may have a circadian rhythm in which they feed and this correlates with a circadian rhythm of the microfilariae in the circulation.
  • The highest concentration of microfilariae usually occurs at the time of day when the local vector is most active in feeding.
  • Microfilariae undergo two stages of development in the insect.
  • Larvae at the third stage are then inoculated back into the vertebral host during feeding and the final two stages of development follow.
  • In 2000 over 120 million people were infected, with about 40 million disfigured and incapacitated by the disease.
  • However, lymphatic filariasis can be eliminated by stopping the spread of infection through preventative chemotherapy for people living in areas where the infection is present. 6.2 billion treatments have been delivered to stop the spread of infection since 2000.
  • 947 million people in 54 countries are living in areas that require preventative chemotherapy to stop the spread of infection. Approximately 80% of these people are living in the following 10 countries: Angola, Cameroon, Côte d'Ivoire , Democratic Republic of the Congo, India, Indonesia, Mozambique, Myanmar, Nigeria and the United Republic of Tanzania.
  • Globally, an estimated 25 million men have genital disease and over 15 million people are afflicted with lymphoedema.

Both sexes are affected equally. The rate of infection increases throughout childhood and adolescence, although it may be many years before the clinical features are seen.

Lymphatic filariasis is caused by W. bancrofti, B. malayi, and B. timori. It is spread by mosquitoes of the genera Aedes, Anopheles, Culex, and Mansonia. 90% of lymphatic filariasis is caused by W. bancrofti and the rest is mostly caused by B. malayi. B. malayi does not affect genitalia lymphatics.

The symptoms are predominantly the result of adult worms in the lymphatics. There are three broad types of clinical scenarios:

  • Asymptomatic infection.
  • Acute infection.
  • Chronic infection.

Asymptomatic infection

  • This is seen commonly in areas where the disease is endemic.
  • Patients have no symptoms but microfilaria can be detected in peripheral blood smears.
  • These patients will already have irreversible lymphatic changes highlighting the importance of their detection and treatment.

Acute infection

This includes acute adeno-lymphangitis (ADL) and acute filarial lymphangitis (AFL).

This is the most common acute presentation. It is characterised by:

  • Fever and painful lymphadenopathy in the groin and axillae.
  • Affected areas being painful, tender, red and swollen - usually the result of superimposed bacterial infection.
  • Occurrence several times in a year and more so in rainy seasons, when the moisture between toes increases, leading to fungal infections which damage the skin, allowing worms to invade.
  • Each episode of ADL enhances the development of lymphoedema.


  • This is rare compared with ADL.
  • It is caused by dying adult worms (either spontaneously or with treatment).
  • It is characterised by small tender nodules at the site of worms dying. This may either be along the involved lymphatic or in the scrotum.
  • Tender and enlarged lymphatics may be seen.
  • There is no fever or secondary infection.

Chronic infection[3]

  • This is manifested by lymphoedema, elephantiasis and lesions of the genitourinary system.
  • Lymphoedema is the most common and may progress to elephantiasis.
  • The lower limbs are most commonly involved - but the upper limbs, genitalia and breast in females may also be involved.
  • Frequent episodes of ADL lead to the progression of lymphoedema.
  • Hydrocele is commonly seen in chronic infection.
  • Chylocele, chyluria and chylous ascites occur rarely.

Tropical pulmonary eosinophilia
This is a form of occult filariasis. Presenting symptoms include:

  • Paroxysmal dry cough.
  • Scattered wheezes and crackles are heard in both lungs.
  • Dyspnoea.
  • Anorexia.
  • Malaise.
  • Weight loss.
  • Lymphadenopathy and hepatomegaly may be found.


The usual means of detecting the parasite is by examination of peripheral blood. Most species, and all those that produce lymphatic involvement, may be detected by this method. It may be necessary to take the blood at a time when the circadian rhythm gives a high count. Another technique is to give a small dose of the drug diethylcarbamazine (DEC) to precipitate them into the circulation.

Immunological tests

Circulating filarial antigen may be detected using commercially available kits to test venous blood. This can be used in diagnosis and to monitor treatment. Antibody tests are also available. Eosinophilia is marked in all forms of filarial infection. Serum IgE and IgG4 are elevated with active disease. Polymerase chain reaction, which have a high specificity and sensitivity, are also available.


If lymphatic filariasis is suspected, urine should be examined macroscopically for chyluria and then concentrated to examine microscopically for microfilariae. Chyluria results from obstruction of lymphatic drainage.


Obstruction of the inguinal and scrotal lymphatics can be demonstrated and monitored by ultrasound. More recently ultrasonography has been used to detect adult worms in male scrotal lymphatics and lymphoscintigraphy has been used to detect lymphatic changes[4].

It is important to appreciate that some of the newer and more sophisticated investigation methods may not be available in areas where the disease is endemic. Thus use of peripheral blood smears and immunological tests is the predominant detection method used.

General measures

  • Bed rest, limb elevation, and compression bandages are the traditional management of lymphoedema.
  • Once infection has occurred a 'foot care programme' is paramount to break the cycle of infection and worsening lymphoedema. This involves washing of the affected area (including webs of the toes and deep folds), wiping the area dry, clipping and cleaning nails, avoiding injuries or infections and applying antifungal substances[4].
  • Prevention of repeated ADLs is also important and may require long-term antibiotic therapy - eg, oral penicillin or long-acting parenteral penicillin. Unfortunately, a lot of these simple measures are not achievable in areas where the disease is endemic due to economic and other political factors.


In accordance with current mass drug administration (MDA) programmes, the mainstay chemotherapy against lymphatic filariasis is combinations of ivermectin and DEC with albendazole[1].

  • DEC is the most commonly used drug and kills both adult worms and microfilariae[4]. It is not licensed for use in the UK but can be used on a named patient basis[6].
  • Treatment of lymphatic filariasis with DEC involves either a 1-day or 12-day treatment course. Generally, 1-day treatment is as effective as the 12-day regimen. DEC is contra-indicated in patients who may also have onchocerciasis.
  • DEC should be given for a longer duration in tropical pulmonary eosinophilia (treatment for 2-3 weeks is usual).
  • Ivermectin kills the microfilariae, but not the adult worm, which is responsible for lymphoedema and hydrocele.

Community treatment

Between 2000-2007, the Global Programme to Eliminate Lymphatic Filariasis delivered more than 1.9 billion treatments to nearly 600 million individuals via annual mass drug administration of antifilarial drugs (albendazole, ivermectin, DEC) to all at risk, for 4-6 years. The programme was very effective and proven to be an excellent investment in global health[7].

  • Filarial diseases are rarely fatal but those affected tend to have poor health, have more time off work and are less productive[8].
  • The World Health Organization has identified lymphatic filariasis as the second leading cause of permanent and long-term disability in the world after leprosy.
  • The morbidity of human filariasis mainly results from the host reaction to microfilariae or developing adult worms in different areas of the body.
  • Avoidance of bites by vectors when in endemic areas. The separate Malaria article discusses avoidance of mosquito bites.
  • Lymphatic filariasis can be eliminated by stopping the spread of infection through preventative chemotherapy for people living in areas where the infection is present[2].

Further reading and references

  1. Kwarteng A, Ahuno ST, Akoto FO; Killing filarial nematode parasites: role of treatment options and host immune response. Infect Dis Poverty. 2016 Oct 35(1):86.

  2. Lymphatic Filariasis; World Health Organization

  3. Yimer M, Hailu T, Mulu W, et al; Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. J Vector Borne Dis. 2015 Jun52(2):111-5.

  4. Palumbo E; Filariasis: diagnosis, treatment and prevention. Acta Biomed. 2008 Aug79(2):106-9.

  5. Lymphatic Filariasis; DPDx, Centers for Disease Control and Prevention

  6. British National Formulary (BNF); NICE Evidence Services (UK access only)

  7. Chu BK, Hooper PJ, Bradley MH, et al; The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000-2007). PLoS Negl Trop Dis. 2010 Jun 14(6):e708. doi: 10.1371/journal.pntd.0000708.

  8. Babu BV, Swain BK, Rath K; Impact of chronic lymphatic filariasis on quantity and quality of productive work among weavers in an endemic village from India. Trop Med Int Health. 2006 May11(5):712-7.