Postmenopausal Bleeding

Authored by , Reviewed by Dr Sarah Jarvis MBE | Last edited | Certified by The Information Standard

This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Periods and Period Problems article more useful, or one of our other health articles.

Postmenopausal bleeding (PMB) is defined for practical purposes as vaginal bleeding occurring after twelve months of amenorrhoea, in a woman of the age where the menopause can be expected.

Hence it does not apply to a young woman, who has had amenorrhoea from anorexia nervosa, or a pregnancy followed by lactation. However, it can apply to younger women following premature ovarian insufficiency or premature menopause.

Unscheduled bleeding in women of menopausal age taking hormone replacement therapy (HRT) should be managed in the same way from a practical perspective. 'Unscheduled bleeding' is defined as non-cyclical bleeding still continuing six months after commencing HRT or after six months of amenorrhoea.

Although PMB usually has a benign cause, the priority is to exclude malignancy.

PMB is a common problem representing 5% of all gynaecology outpatient attendances. These are most commonly to eliminate endometrial cancer as the cause of the bleed.

Risk factors for endometrial cancer[1]

Protective factors for endometrial cancer

History and examination may possibly indicate cause, but it is generally accepted that PMB should be treated as malignant, until proved otherwise.

This requires referral to a gynaecologist with an appointment within two weeks[2]

Transvaginal ultrasound scan (TVUS)

TVUS is an appropriate first-line procedure to identify which women with PMB are at higher risk of endometrial cancer[3].

The mean endometrial thickness in postmenopausal women is much thinner than in pre-menopausal women. Thickening of the endometrium may indicate the presence of pathology. In general, the thicker the endometrium, the higher the likelihood of important pathology, ie endometrial cancer being present.

The threshold in the UK and the USA is 5 mm. There is some uncertainty regarding the optimal cutoff for endometrial thickness. Several meta-analyses that have used a cutoff measurement of 5 mm or less had a 96% sensitivity and a post-test probability of 2.5% for endometrial cancer in postmenopausal women[1]. However, there is a false positive rate of over 70%[4].

Endometrial biopsy

A definitive diagnosis in PMB is made by histology. Historically, endometrial samples have been obtained by dilatation and curettage. Nowadays it is more usual to obtain a sample by endometrial biopsy, which can be undertaken using samplers. It is most often done as an outpatient procedure, in a hospital or community clinic, or sometimes a GP surgery[5, 6].

When an adequate sample is obtained, the PipelleĀ® method has high diagnostic accuracy, with a positive predictive value of 81.7% and a negative predictive value of 99.1%[1]. However, adequate samples can be difficult to obtain. One study showed that only 34% of patients had an adequate sample. This percentage rose to 60% when evaluating women with an endometrial thickness of at least 5 mm.

NB: every method of sampling the endometrium has the potential to miss some cancers.

Hysteroscopy

Hysteroscopy and biopsy (curettage) are the preferred diagnostic technique to detect polyps and other benign lesions. Hysteroscopy may be performed as an outpatient procedure, although some women will need GA[7].

Referral to 'one stop' specialised clinics is ideal[8]. At such clinics several investigations are available to complement clinical evaluation, including ultrasound, endometrial sampling techniques and hysteroscopy. Following such assessment, reassurance can be given or further investigations or treatment can be discussed and arranged.

Most women with PMB will not have significant pathology but the dictum remains that postmenopausal bleeding is cancer until proved otherwise.

  • PMB in women on HRT still needs investigation.
  • An obvious lesion such as atrophic vaginitis does not exclude another lesion.
  • Many women are unable to distinguish between vaginal and urinary bleeding and some are unable to distinguish rectal bleeding.

Tamoxifen

Women with breast cancer who take tamoxifen on a long-term basis are at increased risk of endometrial cancer. In view of the increased risk of endometrial cancer associated with tamoxifen therapy, there is a case for heightened vigilance for PMB by both the women and the clinician(s) responsible for their care. Tamoxifen can cause other changes to the endometrium, and ultrasound may be more difficult to interpret. All women with PMB who are on tamoxifen would normally have hysteroscopy and biopsy in addition to ultrasonography.

Further reading and references

  1. Braun MM, Overbeek-Wager EA, Grumbo RJ; Diagnosis and Management of Endometrial Cancer. Am Fam Physician. 2016 Mar 1593(6):468-74.

  2. Suspected cancer: recognition and referral; NICE Clinical Guideline (2015 - last updated July 2017)

  3. Wong AW, Lao TH, Cheung CW, et al; Reappraisal of endometrial thickness for the detection of endometrial cancer in postmenopausal bleeding: a retrospective cohort study. BJOG. 2015 Mar 20. doi: 10.1111/1471-0528.13342.

  4. Schramm A, Ebner F, Bauer E, et al; Value of endometrial thickness assessed by transvaginal ultrasound for the prediction of endometrial cancer in patients with postmenopausal bleeding. Arch Gynecol Obstet. 2017 Aug296(2):319-326. doi: 10.1007/s00404-017-4439-0. Epub 2017 Jun 20.

  5. Dickson JM, Delaney B, Connor ME; Primary care endometrial sampling for abnormal uterine bleeding: a pilot study. J Fam Plann Reprod Health Care. 2017 Oct43(4):296-301. doi: 10.1136/jfprhc-2017-101735. Epub 2017 Aug 19.

  6. Narice BF, Delaney B, Dickson JM; Endometrial sampling in low-risk patients with abnormal uterine bleeding: a systematic review and meta-synthesis. BMC Fam Pract. 2018 Jul 3019(1):135. doi: 10.1186/s12875-018-0817-3.

  7. Centini G, Troia L, Lazzeri L, et al; Modern operative hysteroscopy. Minerva Ginecol. 2016 Apr68(2):126-32. Epub 2016 Mar 1.

  8. Lotfallah H, Farag K, Hassan I, et al; One-stop hysteroscopy clinic for postmenopausal bleeding. J Reprod Med. 2005 Feb50(2):101-7.

The day started like they all do... actually there really isnt an end to the day because i toss and turn all night, weird vivid dreams, digestive issues and so on. You open up your eyes to get...

susan39015
Health Tools

Feeling unwell?

Assess your symptoms online with our free symptom checker.

Start symptom checker
newnav-downnewnav-up