Prostate cancer is a serious condition. The prostate specific antigen (PSA) test is a blood test to see if you might have prostate cancer and to monitor treatment for prostate cancer.
The PSA blood level is also increased in other conditions. So having an increased PSA test result does not mean that you have prostate cancer. Experts disagree on how useful the PSA test is. There is a lot of ongoing research about PSA. At the moment there is no national screening programme for prostate cancer in the UK.
What is the prostate gland?
The prostate gland (just called prostate from now on) is only found in men. It lies just beneath the bladder. It is normally about the size of a chestnut.
The tube which passes urine from the bladder (this is called the urethra) runs through the middle of the prostate. The prostate's main function is to produce fluid which protects and enriches sperm.
The prostate often gets bigger (enlarges) gradually after the age of about 50. By the age of 70, about 8 in 10 men have an enlarged prostate. It is common for older men to have urinary symptoms caused by a non-cancerous (benign) enlargement of the prostate. Some men also develop prostate cancer. See separate leaflet called Prostate Gland Enlargement for more details.
What is prostate cancer?
Prostate cancer is a cancer which develops from cells in the prostate gland. It is the most common cancer in men in the UK. Each year, about 40,000 men are diagnosed with prostate cancer in the UK. It affects about 1 in 9 men in the UK at some point in their lives. Most cases develop in men over the age of 65.
Prostate cancer is different to most other cancers because small areas of cancer within the prostate are actually very common, especially in older men. These may not grow or cause any problems for many years (if at all). See separate leaflet called Prostate Cancer for more details.
What is a prostate specific antigen (PSA) test?
The PSA test is a blood test that measures the level of PSA in your blood. PSA is made by the prostate gland. The PSA level in your bloodstream is measured in nanograms per millilitre (ng/mL).
When you have a PSA test, you should not have:
- An active urine infection.
- Produced semen during sex or masturbation (ejaculated) in the previous 48 hours.
- Exercised heavily in the previous 48 hours.
- Had a prostate biopsy in the previous six weeks.
- Had an examination of the back passage with a gloved finger (a digital rectal examination) in the previous week.
Each of these may produce an unusually high PSA result.
If you decide to have a PSA test, your doctor will give you a digital rectal examination to feel the prostate. This is to find out if the prostate is enlarged or feels abnormal in any way.
March 2018 - Dr Hayley Willacy draws your attention to the newly released Public Health England advice available in the Further reading section below. The guidance helps GPs give clear and balanced information to men who do not have symptoms when they ask about prostate specific antigen testing. The PSA test is available free to any well man aged 50 and over who requests it. GPs should use their clinical judgement to manage men with symptoms and those aged under 50 who are considered to have higher risk for prostate cancer.
What is a normal result?
The normal range changes as you get older.
PSA Cut-off Values
|40-49||2.0 nanogram/mL or higher|
|50-59||3.0 nanogram/mL or higher|
|60-69||4.0 nanogram/mL or higher|
|70 or older||5.0 nanogram/mL or higher|
|There are no age-specific reference limits for men older than 80 years of age.|
The higher the level of prostate specific antigen (PSA), the more likely it is to be a sign of cancer.
The PSA test can also miss cancer. About 15 in every 100 men who have prostate cancer will have had a normal PSA level. A one-off test is not reliable and repeating the test may provide important information.
What causes a raised prostate specific antigen (PSA) level?
A raised PSA level may mean you have prostate cancer but about two out of three men with a raised PSA level will not have prostate cancer.
Other conditions may also cause a raised PSA level, including:
- Inability to pass urine, causing an enlarged bladder (acute retention of urine).
- Enlargement of the prostate that is non-cancerous (benign).
- Older age.
- Urine infection.
- Acute prostatitis.
- Transurethral resection of the prostate (TURP) operation. TURP is an operation used to remove the prostate if you have benign enlargement of the prostate.
- If you have a tube (catheter) to help pass urine
What happens after a prostate specific antigen (PSA) test?
If your PSA level is not raised
You are unlikely to have cancer. No immediate further action is needed but you may need further tests to confirm the result.
If your PSA level is slightly raised
You probably do not have cancer. You might need further tests, including more PSA tests.
If your PSA level is definitely raised
Your GP will refer you to see a doctor who is a specialist for you to have further tests to find out if you have prostate cancer. The specialist will discuss with you the options for further investigations, which may include a sample taken (a biopsy) of your prostate gland and an MRI scan.
If prostate cancer is found, what are my options?
Further reading and references
Advising well men aged 50 and over about the PSA test for prostate cancer: information for GPs; Public Health England (2018)
Prostate cancer; NICE CKS, January 2011 (UK access only)
Moyer VA; Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012 Jul 17157(2):120-34. doi: 10.7326/0003-4819-157-2-201207170-00459.
Ilic D, Neuberger MM, Djulbegovic M, et al; Screening for prostate cancer. Cochrane Database Syst Rev. 2013 Jan 311:CD004720. doi: 10.1002/14651858.CD004720.pub3.
Wilt TJ, Ahmed HU; Prostate cancer screening and the management of clinically localized disease. BMJ. 2013 Jan 29346:f325. doi: 10.1136/bmj.f325.
After 25 years of BPH I was MRI diagnosed with 3+4 PCa in 2015. Post Open RP I was staggered to discover a possible link between my 12 months of Dutasteride treatment in 2013/14 and serious PCa. My...barrie62598
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