Can I take 1.25 and Citalopram together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking cannabis with citalopram can increase the risk of side effects like drowsiness, dizziness, and confusion. It may also increase the risk of a rare but serious condition called serotonin syndrome, which can cause a fast heartbeat, sweating, and muscle stiffness. Additionally, cannabis can sometimes make the symptoms of depression or anxiety worse, which may interfere with how well citalopram works for you.
In this article:
Continue reading below
Why this happens
Both substances affect chemicals in the brain, particularly serotonin. Combining them can lead to an additive effect on the central nervous system. Furthermore, cannabis may interfere with the liver enzymes that break down citalopram, potentially leading to higher levels of the medicine in your blood.
What you should do
Back to contentsYou should speak to your doctor before using cannabis while taking citalopram. If you experience any unusual symptoms like extreme agitation, a very fast heartbeat, or severe confusion, seek medical help immediately. It is also important to note that it is illegal to drive with any cannabis in your system in the UK, regardless of whether you feel impaired.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take 150 and Zigduo together?
Taking aspirin (75mg to 150mg) with Xigduo (which contains dapagliflozin and metformin) can increase the risk of your blood sugar dropping too low (hypoglycaemia). It may also increase the risk of a rare but serious condition called lactic acidosis, where too much acid builds up in your blood.

Treatment and medication
Can I take Alodipine and Bisoprolol together?
Taking amlodipine and bisoprolol together can cause your blood pressure to drop lower than if you took either medicine alone. It can also significantly slow down your heart rate. This may make you feel dizzy, lightheaded, faint, or unusually tired.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.