Can I take 100 and Omeprazole together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Omeprazole can significantly reduce the amount of 100 (posaconazole) that your body absorbs. This means the antifungal medicine may not work well enough to treat or prevent your infection.
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Why this happens
Posaconazole (100) needs a highly acidic environment in the stomach to dissolve properly so it can be absorbed into the bloodstream. Omeprazole works by reducing stomach acid, which prevents the posaconazole from dissolving and entering your system.
What you should do
Back to contentsYou should avoid taking omeprazole while you are taking posaconazole (100) tablets or oral suspension. If you need treatment for acid reflux, speak to your doctor; they may suggest an alternative or monitor you very closely. Do not stop taking your prescribed medicines without consulting your healthcare provider first.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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