Can I take 7.5mg and Medikinet together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking Zopiclone and Medikinet (methylphenidate) together can cause a 'tug-of-war' effect in your body. Medikinet is a stimulant designed to wake you up and help you focus, while Zopiclone is a sedative designed to make you sleepy. Taking them at the same time can make both medicines less effective. Additionally, while Medikinet is active, it may be harder for you to fall asleep, even after taking Zopiclone. In some cases, mixing stimulants and sedatives can lead to unpredictable effects on your coordination, heart rate, or mental state (such as feeling confused or agitated).
In this article:
Continue reading below
Why this happens
This is a pharmacodynamic interaction. Medikinet increases the activity of certain chemicals in the brain (dopamine and norepinephrine) to stimulate the central nervous system. Zopiclone works by increasing the activity of a calming chemical (GABA) to slow down the central nervous system. Because they have opposite effects, they can mask each other's actions.
What you should do
Back to contentsYou should use caution when taking these two medicines. Ensure you are taking them at the correct times as prescribed by your doctor—usually Medikinet in the morning/afternoon and Zopiclone strictly at bedtime. Do not drive or operate machinery if you feel 'foggy', confused, or less alert the next morning. If you find that your sleep does not improve or your daytime focus is worse, speak to your doctor, as they may need to adjust the timing or dosage of your medication.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Atorvastatin and Magnesium together?
Taking magnesium antacids at the same time as atorvastatin can lower the amount of the statin medicine that your body absorbs. This might make your cholesterol treatment less effective.

Treatment and medication
Can I take Alodipine and Bisoprolol together?
Taking amlodipine and bisoprolol together can cause your blood pressure to drop lower than if you took either medicine alone. It can also significantly slow down your heart rate. This may make you feel dizzy, lightheaded, faint, or unusually tired.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.