Can I take 12.5mg and Alogliptin together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known interaction between hydrochlorothiazide (12.5mg) and alogliptin. However, because hydrochlorothiazide is a 'water pill' (diuretic) used for blood pressure and alogliptin is for type 2 diabetes, they can sometimes have opposing effects on your blood sugar levels.
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Why this happens
Hydrochlorothiazide can occasionally make the body less sensitive to insulin or cause the body to lose potassium, both of which can slightly raise blood sugar levels. Alogliptin works to lower blood sugar. While 12.5mg is a very low dose of hydrochlorothiazide and unlikely to cause issues, it technically works against the goal of the diabetes medication.
What you should do
You can safely take these medicines together. It is good practice to monitor your blood sugar levels regularly when starting or changing the dose of a diuretic. If you notice your blood sugar readings are consistently higher than usual, mention it to your doctor or pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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