Can I take Black cohosh and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known significant interactions between black cohosh and vitamin D. It is generally considered safe to take these two supplements together.
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Why this happens
Black cohosh and vitamin D are processed by the body through different pathways. Black cohosh is primarily broken down by liver enzymes, while vitamin D is a fat-soluble vitamin that undergoes a different metabolic process involving the liver and kidneys to become active. They do not interfere with each other's absorption or effectiveness.
What you should do
Back to contentsYou can continue taking both supplements as directed. However, always inform your doctor or pharmacist about all supplements you are taking, especially if you have a history of liver problems, as black cohosh has been rarely linked to liver issues.
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Important precautions
Back to contentsPregnancy
Do not use black cohosh during pregnancy. It may stimulate uterine contractions, potentially increasing the risk of miscarriage or premature labour.
Liver disease
Black cohosh has been linked to rare but serious cases of liver failure. You must stop taking it and see a doctor immediately if you develop yellowing of the skin or eyes, dark urine, or severe stomach pain.
Hormone-sensitive conditions (e.g. breast cancer)
Because black cohosh may act like the hormone oestrogen, you should not use it if you have a history of breast cancer, uterine cancer, or endometriosis without specialist medical supervision.
Food and drink warnings
Back to contentsAlcohol
Black cohosh has been linked to rare but serious cases of liver damage. Because alcohol also puts strain on the liver, it is advisable to limit or avoid alcohol consumption while taking this supplement to reduce the risk of liver toxicity.
High-fat meals
Vitamin D is a fat-soluble vitamin. Taking it with a meal that contains healthy fats (such as avocado, nuts, or olive oil) significantly improves how well your body absorbs the supplement.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Levothyroxine and Vitamin D together?
There is no direct harmful interaction between levothyroxine and vitamin D. In fact, many people take them together because vitamin D deficiency is common in people with thyroid conditions. However, if your vitamin D supplement also contains calcium, it can significantly interfere with how your body absorbs your thyroid medication.

Treatment and medication
Can I take Levothyroxine and Prednisolone together?
Taking prednisolone may change how much levothyroxine your body needs. You might find that your thyroid levels fluctuate, potentially leading to symptoms of an overactive or underactive thyroid while you are on the steroid treatment.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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