Can I take Black cohosh and Vitamin d together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There are no known significant interactions between black cohosh and vitamin D. It is generally considered safe to take these two supplements together.
In this article:
Continue reading below
Why this happens
Black cohosh and vitamin D are processed by the body through different pathways. Black cohosh is primarily broken down by liver enzymes, while vitamin D is a fat-soluble vitamin that undergoes a different metabolic process involving the liver and kidneys to become active. They do not interfere with each other's absorption or effectiveness.
What you should do
You can continue taking both supplements as directed. However, always inform your doctor or pharmacist about all supplements you are taking, especially if you have a history of liver problems, as black cohosh has been rarely linked to liver issues.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Ashwagandha and Oestrogel pump-pack /actuation together?
Ashwagandha may increase the levels of oestrogen in your body, potentially making the effects of your Oestrogel stronger than intended. It might also interfere with how your body naturally balances hormones.

Treatment and medication
Can I take Ibuprofen gel 10% and Shortec together?
Using ibuprofen gel alongside Shortec (oxycodone) is generally safe, but there is a small risk of increased side effects such as drowsiness, dizziness, or stomach irritation if the ibuprofen is absorbed into the bloodstream in significant amounts.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.