Can I take 12.5mg and Apixaban together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking aspirin and apixaban together significantly increases your risk of serious bleeding. This includes internal bleeding, such as in the stomach or brain, as well as bleeding from the gums, nosebleeds, or bruising that happens more easily than usual.
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Why this happens
Both medicines work to prevent blood clots but in different ways. Apixaban is an anticoagulant (blood thinner) that interferes with clotting proteins, while aspirin is an antiplatelet medicine that stops blood cells from sticking together. Using both at the same time makes the blood much less likely to clot, which increases the risk of haemorrhage (uncontrolled bleeding).
What you should do
Do not take aspirin with apixaban unless your doctor has specifically told you to do so for a particular medical reason (such as having a heart stent). If you need pain relief, paracetamol is generally a safer choice. If you are already taking both, do not stop without talking to your doctor, but seek immediate medical help if you notice signs of bleeding, such as black tarry stools, blood in your urine, or coughing up blood.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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