Can I take 12.5mg and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking Rybelsus (semaglutide) alongside atenolol may increase the risk of your blood sugar levels dropping too low (hypoglycaemia). Additionally, atenolol can 'mask' or hide the common warning signs of low blood sugar, such as a fast heartbeat or palpitations.
In this article:
Continue reading below
Why this happens
Rybelsus lowers blood sugar. While atenolol is for blood pressure, it can also lower blood sugar or make it harder for your body to recover from a 'sugar crash'. Crucially, atenolol blocks the 'fight or flight' response (adrenaline) that usually causes your heart to race when your sugar is low, meaning you might not realise you are in danger until the symptoms are severe.
What you should do
You can take these together, but you must be extra vigilant. Monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise other signs of low blood sugar that atenolol doesn't hide, such as sweating, dizziness, hunger, or confusion. If you feel unwell, treat the low sugar immediately and inform your GP.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Idapamide and Ramipril together?
Taking indapamide and ramipril together can cause your blood pressure to drop too low, especially when you first start the combination. This can make you feel dizzy, lightheaded, or faint. It can also put extra strain on your kidneys.

Treatment and medication
Can I take Hydroxycarbamide and Hydroxychloroquine together?
Both hydroxycarbamide and hydroxychloroquine can lower your blood cell counts. Taking them together may increase the risk of developing serious infections, anaemia (low red blood cells), or bruising and bleeding problems. There is also a small risk that both medications could affect your heart rhythm or increase the risk of skin reactions.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.