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Can I take 12.5mg and Rybelsus together?

Drug interaction guide

Taking Rybelsus (semaglutide) alongside atenolol may increase the risk of your blood sugar levels dropping too low (hypoglycaemia). Additionally, atenolol can 'mask' or hide the common warning signs of low blood sugar, such as a fast heartbeat or palpitations.

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Why this happens

Rybelsus lowers blood sugar. While atenolol is for blood pressure, it can also lower blood sugar or make it harder for your body to recover from a 'sugar crash'. Crucially, atenolol blocks the 'fight or flight' response (adrenaline) that usually causes your heart to race when your sugar is low, meaning you might not realise you are in danger until the symptoms are severe.

What you should do

You can take these together, but you must be extra vigilant. Monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise other signs of low blood sugar that atenolol doesn't hide, such as sweating, dizziness, hunger, or confusion. If you feel unwell, treat the low sugar immediately and inform your GP.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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