Can I take Hydroxycarbamide and Hydroxychloroquine together?

Why this happens

These drugs have 'additive' effects on the bone marrow. Hydroxycarbamide is designed to slow down the production of blood cells, and hydroxychloroquine can sometimes cause this as a side effect. When used together, the impact on your immune system and blood count is much stronger.

What you should do

You must speak to your doctor before taking these two medicines together. If your doctor decides you need both, you will require very frequent blood tests to monitor your full blood count. Seek immediate medical help if you develop a fever, sore throat, unusual bruising, or extreme tiredness.

Important precautions

Pregnancy and Contraception

Hydroxycarbamide can cause serious birth defects. Both men and women must use effective contraception during treatment and for several months after stopping (3 months for women, 6 months for men).

Vision Changes

Hydroxychloroquine can cause permanent damage to the retina. You must have regular eye tests and report any blurred vision or changes in your sight immediately.

Infection and Bleeding

Hydroxycarbamide can severely lower your white blood cell count. You must seek urgent medical attention if you develop signs of infection (fever, sore throat) or unexplained bruising/bleeding.

Sun Exposure

Hydroxycarbamide significantly increases your risk of developing skin cancer. You must protect your skin from sunlight by using high-factor sunscreen (SPF 30 or higher) and wearing protective clothing.

Handling and Hygiene

Hydroxycarbamide is a cytotoxic medicine. You must wear gloves when handling the capsules or cleaning up any body fluids (like urine or vomit) to prevent others from being exposed to the drug. Wash your hands thoroughly after handling.

Heart rhythm disorders

Hydroxychloroquine can affect your heart rhythm, especially if taken with other medicines that affect the heart. Seek immediate medical help if you experience palpitations, fainting, or severe dizziness.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with hydroxycarbamide can increase the risk of liver damage and worsen side effects like dizziness or drowsiness. Hydroxychloroquine can also affect the liver, and alcohol may increase this risk.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.