Can I take 50 and Diflucan together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking 5-HTP and Diflucan (fluconazole) together can increase the levels of serotonin in your brain. This can lead to a rare but serious condition called serotonin syndrome. Symptoms can include shivering, diarrhoea, confusion, severe muscle tightness, fever, and seizures.
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Why this happens
Diflucan (fluconazole) can slow down the enzymes in your liver that break down 5-HTP. This causes 5-HTP to stay in your system longer and build up to higher levels than intended, leading to excessive serotonin activity.
What you should do
Back to contentsYou should speak to your doctor or pharmacist before taking these two together. If you are already taking them and feel unwell, particularly if you experience confusion, a very fast heartbeat, or muscle twitching, seek medical help immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking paracetamol (acetaminophen) and levocetirizine together is generally considered safe. There are no known major interactions between these two medicines. However, both can occasionally cause drowsiness or tiredness in some people. If you experience these side effects, they may be slightly more noticeable when taking both medicines at the same time.
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Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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