Can I take 50xl and Aspirin together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking these two medicines together significantly increases your risk of internal bleeding, particularly in the stomach or gut. It can also lead to serious kidney problems.
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Why this happens
Both medicines belong to a group called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). They work by blocking certain enzymes in the body. When you take two different NSAIDs together, you 'double up' on the side effects without getting extra pain relief. This thins the stomach lining and reduces blood flow to the kidneys.
What you should do
Back to contentsDo not take these two medicines together. If you have been prescribed both by a doctor, speak to them or a pharmacist immediately before taking another dose. If you experience severe stomach pain, black tarry stools, or vomit that looks like coffee grounds, seek emergency medical help.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
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Taking amlodipine and bisoprolol together can cause your blood pressure to drop lower than if you took either medicine alone. It can also significantly slow down your heart rate. This may make you feel dizzy, lightheaded, faint, or unusually tired.
Treatment and medication
Can I take Desmopressin and Ketoconazole together?
Taking these two medicines together can significantly increase the amount of desmopressin in your blood. This can lead to your body holding onto too much water, which can cause a dangerous drop in your blood salt levels (hyponatraemia). Symptoms to watch for include severe headache, nausea, vomiting, confusion, or feeling very drowsy.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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