Can I take Adanif and Ibuprofen together?

Why this happens

Afatinib is transported in the body by a protein called P-glycoprotein (P-gp). Ibuprofen can interfere with this protein, potentially causing levels of afatinib to rise too high in your blood. Additionally, both drugs can be harsh on the lining of the digestive tract, leading to an increased risk of irritation or bleeding.

You should avoid taking ibuprofen while you are on afatinib unless specifically told to do so by your specialist. If you need pain relief, paracetamol is usually a safer alternative. If you must take them together, your doctor may advise you to space the doses at least 6 to 12 hours apart. Contact your doctor immediately if you develop severe diarrhoea, a painful skin rash, or notice any signs of bleeding (such as dark, tarry stools).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.