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Can I take Alandrosic accid and Clopodogrel together?

Drug interaction guide

Taking alendronic acid and clopidogrel together can increase your risk of developing irritation, inflammation, or ulcers in your stomach and oesophagus (the food pipe). Both medications can be hard on the lining of the digestive tract.

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Why this happens

Alendronic acid is known to cause local irritation to the lining of the stomach and food pipe. Clopidogrel is an antiplatelet (blood thinner) that prevents blood clots; however, by thinning the blood, it can make any small irritation or injury in the stomach more likely to bleed or turn into an ulcer.

You can take these together, but you must follow the instructions for alendronic acid very carefully: take it first thing in the morning on an empty stomach with a full glass of plain water, and remain fully upright (sitting or standing) for at least 30 minutes. Do not lie down until after you have eaten your first food of the day.

Contact your doctor immediately if you notice severe indigestion, heartburn, pain when swallowing, or black, tarry stools.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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