Can I take Allopurinol and Ibrutinib together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There is no direct interaction between allopurinol and ibrutinib. However, they are often prescribed together to manage a specific complication called 'Tumour Lysis Syndrome' (TLS). While they do not interfere with each other's metabolism, taking them together requires careful monitoring of your kidney function and blood counts by your medical team.
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Why this happens
Allopurinol lowers uric acid levels in the blood, while ibrutinib works by killing cancer cells. When cancer cells die quickly (which can happen when starting ibrutinib), they release substances that can harm the kidneys. Allopurinol is used to protect the kidneys during this process. There is no evidence that one drug changes the concentration or effectiveness of the other in the body.
What you should do
Back to contentsIt is safe to take these medicines together as prescribed by your specialist. Ensure you stay well-hydrated by drinking plenty of water, as this helps both medications work safely. If you notice any new skin rashes, severe bruising, or changes in how much you urinate, contact your doctor or oncology team immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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