Can I take Am and Sertraline together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking St John's Wort (Hypericum perforatum) with sertraline can lead to a serious condition called serotonin syndrome. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, sweaty, shaky, or having a fast heartbeat. In severe cases, it can be dangerous.
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Why this happens
Both sertraline and St John's Wort increase the levels of serotonin in the brain. When used together, they can raise these levels to a point that becomes toxic to the body. Additionally, St John's Wort can change how your liver processes sertraline, making the levels of the medicine in your blood unpredictable.
What you should do
Back to contentsDo not take St John's Wort if you are already taking sertraline. If you are currently taking both, do not stop suddenly, but contact your GP or pharmacist immediately for advice on how to stop safely. If you experience severe shivering, fever, or confusion, seek urgent medical help.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take Acetaminophen and Levocetirizine together?
Taking paracetamol (acetaminophen) and levocetirizine together is generally considered safe. There are no known major interactions between these two medicines. However, both can occasionally cause drowsiness or tiredness in some people. If you experience these side effects, they may be slightly more noticeable when taking both medicines at the same time.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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