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Can I take Amitriptyline and Jardiance together?

Drug interaction guide

Taking amitriptyline and Jardiance (empagliflozin) together may increase the risk of becoming dehydrated or feeling dizzy when you stand up. Both medications can affect your blood pressure and fluid levels in different ways.

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Why this happens

Jardiance works by removing sugar and extra fluid from the body through urine, which can lower blood pressure. Amitriptyline can cause 'orthostatic hypotension,' which is a sudden drop in blood pressure when you change positions (like standing up from a chair). Together, these effects can make you feel lightheaded or faint.

You can usually take these together, but you should be careful. Make sure you drink plenty of water to stay hydrated. When getting out of bed or standing up from a chair, do so slowly to give your body time to adjust. If you feel very dizzy, faint, or notice you are urinating much less than usual, speak to your doctor.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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