Can I take Amitriptyline and Trazodone together?

Why this happens

Both drugs increase the levels of a chemical called serotonin in the brain; too much serotonin can lead to toxicity. Additionally, both drugs have sedative effects and can interfere with the electrical signals in the heart (QT prolongation).

What you should do

You should only take these two medications together if specifically prescribed by a specialist who is monitoring you closely. Seek immediate medical help if you experience a very fast or irregular heartbeat, severe dizziness, fainting, muscle stiffness, tremors, or high fever. Avoid driving or operating machinery until you know how this combination affects you.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.