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Can I take Evolocumab and Ezetimibe together?

Drug interaction guide

Originally published 25 Jan 2026

Meets Patient’s editorial guidelines

Taking evolocumab and ezetimibe together is a common and safe combination. Both medicines work to lower your 'bad' cholesterol (LDL), and using them together helps lower it more effectively than using either one alone. There is no evidence that they interfere with each other in a harmful way.

Why this happens

These drugs work in different ways to achieve the same goal. Ezetimibe reduces the amount of cholesterol your body absorbs from food, while evolocumab (a PCSK9 inhibitor) helps your liver clear more cholesterol out of your blood. Because they use different pathways, they have an 'additive' effect, meaning they work together to improve your results without changing how the other drug is processed by the body.

What you should do

You can safely take these two medicines together as prescribed by your doctor. Ensure you continue to follow any dietary advice provided by your healthcare team and attend your regular blood tests to monitor your cholesterol levels.

Important precautions

Latex allergy - evolocumab

The needle cover of the pre-filled pen or syringe contains dry natural rubber (a derivative of latex), which may cause severe allergic reactions in people with a latex sensitivity.

Liver disease

You must not take ezetimibe if you have active liver disease or unexplained persistent elevations in liver enzymes.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Both evolocumab and ezetimibe are used to lower cholesterol, and regular or heavy alcohol consumption can increase the risk of liver problems and interfere with the effectiveness of your treatment.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.

  • 25 Jan 2026 | Originally published
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