Can I take Amlodipine and Ezetimibe together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There is no known harmful interaction between amlodipine and ezetimibe. These two medicines work in different ways to help your heart and blood vessels. Amlodipine helps to lower blood pressure, while ezetimibe lowers cholesterol. Taking them together is common and generally considered safe.
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Why this happens
Amlodipine is a calcium channel blocker that relaxes blood vessels, and ezetimibe works in the digestive tract to reduce cholesterol absorption. They do not interfere with each other's metabolism or absorption in the body.
What you should do
Back to contentsYou can continue taking both medicines as prescribed by your doctor. It is usually best to take them at the same time each day to help you remember. If you experience any new or unusual side effects, such as muscle pain or swelling in your ankles, mention this to your doctor or pharmacist at your next appointment.
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Important precautions
Back to contentsGrapefruit juice consumption
Avoid drinking large amounts of grapefruit juice. It can increase the level of amlodipine in your blood, making your blood pressure drop too low and increasing the risk of side effects.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the amount of amlodipine in your blood. This may cause your blood pressure to drop too low or increase the risk of side effects like headaches, flushing, or swollen ankles. While small amounts are usually fine, it is best to avoid drinking large quantities of grapefruit juice.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Amlodipine besilate and Msm together?
There is no evidence of a direct interaction between amlodipine and MSM. However, MSM may have a very mild blood-thinning effect or slightly lower blood pressure in some people. When taken with amlodipine, this could theoretically lead to blood pressure dropping slightly lower than intended, though this is not common.
Treatment and medication
Can I take Amlodipine and Statins together?
Taking amlodipine with certain statins (especially simvastatin or atorvastatin) can increase the level of the statin in your blood. This increases the risk of side effects, particularly muscle aches, pains, or weakness (a condition called myopathy). In rare cases, this can lead to a serious muscle breakdown problem called rhabdomyolysis, which can damage the kidneys.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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