Can I take Amlodipine and Valsartan together?

You can take amlodipine and valsartan together and they are often found in a single 'combination pill'.

You should monitor your blood pressure regularly at home when taking these medicines as they can cause your blood pressure to drop lower than if you only took one or the other.

To avoid dizziness, try to get up slowly from a sitting or lying position. Ensure you attend your scheduled blood tests to check your kidney function and potassium levels. If you feel severely dizzy or faint, contact your doctor.

Why this happens

Both medicines work to lower blood pressure but in different ways: amlodipine relaxes the blood vessels directly, while valsartan blocks a hormone that causes blood vessels to tighten. Because they attack the problem from two different angles, their effects add together (an additive effect).

Important precautions

Pregnancy

You must not take valsartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters. If you think you are pregnant, stop taking it and contact your doctor immediately.

High potassium levels (hyperkalaemia)

Avoid using salt substitutes containing potassium or taking potassium supplements unless directed by your doctor, as valsartan can cause dangerously high potassium levels in your blood.

Gum health (gingival hyperplasia)

Amlodipine can cause your gums to swell or grow over your teeth. It is essential to maintain excellent oral hygiene and have regular dental check-ups to manage this risk.

Food and drink warnings

Grapefruit and grapefruit juice

Grapefruit can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. It is best to avoid grapefruit products while taking this medicine.

Alcohol

Drinking alcohol can increase the blood pressure-lowering effect of these medicines. This can make you feel dizzy, lightheaded, or faint, especially when standing up. It is best to keep alcohol intake to a minimum, especially when starting treatment or changing doses.

Salt substitutes (containing potassium)

Valsartan can increase the levels of potassium in your blood. Many salt substitutes contain potassium chloride instead of sodium. Using these while taking valsartan can lead to dangerously high potassium levels (hyperkalaemia). Check with your pharmacist before using salt substitutes.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.