Can I take Amlodopine and Thyroxine together?
Drug interaction guide
Originally published 12 May 2026
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There is no direct interaction between amlodipine and levothyroxine (thyroxine). However, if your thyroid levels are not well-controlled, it can affect how well your blood pressure medication works.
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Why this happens
Amlodipine is a calcium channel blocker used for high blood pressure, and levothyroxine is a hormone replacement for an underactive thyroid. They do not interfere with each other's absorption or metabolism. However, thyroid hormones naturally affect heart rate and blood pressure; therefore, changes in your thyroid dose might indirectly change how much amlodipine you need.
What you should do
Back to contentsYou can safely take these two medicines together. It is usually best to take levothyroxine on an empty stomach first thing in the morning (30-60 minutes before breakfast) to ensure it is absorbed properly. Amlodipine can be taken at any time of day, with or without food. Continue to have your regular blood tests to monitor your thyroid levels and blood pressure.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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