Can I take Amlodopine and Tramadol together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking these two medicines together can cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when standing up quickly. There is also a small risk that tramadol could slightly interfere with how amlodipine is processed in your body, though the main concern is the combined effect on your blood pressure and heart rate.
In this article:
Continue reading below
Why this happens
Both drugs can lower blood pressure through different pathways. Amlodipine relaxes your blood vessels, while tramadol can affect the central nervous system and occasionally cause 'orthostatic hypotension' (a drop in blood pressure upon standing). Additionally, both are processed by the liver, which can sometimes lead to one drug affecting the levels of the other.
What you should do
It is generally safe to take these together, but you should be cautious. When starting tramadol or increasing your dose, get up slowly from a sitting or lying position to avoid dizziness. If you feel very dizzy, faint, or notice a very slow heartbeat, contact your doctor. It is a good idea to monitor your blood pressure at home more frequently when you first start taking both.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Evana heavy period relief and Mefenamic acid together?
Taking these two medicines together significantly increases your risk of serious stomach problems, such as stomach ulcers, bleeding, or irritation of the stomach lining. It can also put extra strain on your kidneys.

Treatment and medication
Can I take Bisoprolol and Trimbow pmdi // pressurised inhalation together?
Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Bisoprolol may cause the airways to narrow, making it harder to breathe and potentially triggering asthma or COPD symptoms. It also makes the formoterol in the Trimbow inhaler less effective at opening your airways.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.