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Can I take Bisoprolol and Trimbow pmdi // pressurised inhalation together?

Drug interaction guide

Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Bisoprolol may cause the airways to narrow, making it harder to breathe and potentially triggering asthma or COPD symptoms. It also makes the formoterol in the Trimbow inhaler less effective at opening your airways.

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Why this happens

Bisoprolol is a 'beta-blocker' and formoterol (in Trimbow) is a 'beta-agonist'. They compete for the same receptors in the lungs. Bisoprolol blocks these receptors, which can cause the bronchial tubes to tighten and prevents the inhaler from working properly.

What you should do

You must speak to your doctor before using these together. Doctors generally avoid prescribing beta-blockers like bisoprolol to patients with breathing conditions unless there is no other option. If you must take both, your doctor will monitor your breathing closely. Seek medical help immediately if you experience sudden wheezing or shortness of breath.

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Important precautions

Acute breathing distress

Bisoprolol is a beta-blocker and can cause narrowing of the airways, potentially triggering a severe asthma attack or worsening breathing difficulties. This is particularly important as you are also using Trimbow for a lung condition.

Diabetes

Bisoprolol can mask the warning signs of low blood sugar (hypoglycaemia), such as a fast heartbeat or tremors. You will need to monitor your blood sugar more closely.

Food and drink warnings

Alcohol

Alcohol can increase the blood-pressure-lowering effect of bisoprolol, which may make you feel dizzy, lightheaded, or faint, especially when you first start taking it or when your dose is increased. It is best to limit alcohol intake until you know how the medicine affects you.

Caffeine

Trimbow contains formoterol, a medicine that can increase your heart rate. Consuming large amounts of caffeine (found in coffee, tea, energy drinks, and chocolate) may worsen this effect, leading to palpitations, tremors, or a rapid heartbeat.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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