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Can I take Aspirin 300 and Metformin together?

Drug interaction guide

Taking aspirin and metformin together may slightly increase the risk of your blood sugar levels dropping too low (hypoglycaemia). While this is generally safe for most people, it is important to be aware of the symptoms of low blood sugar.

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Why this happens

Aspirin can make the body more sensitive to insulin and may slightly increase the amount of insulin released. When combined with metformin, this can occasionally lead to a stronger blood-sugar-lowering effect than intended.

What you should do

You can usually take these medicines together, but you should monitor your blood sugar levels more closely, especially when starting or changing the dose of aspirin. Learn to recognise signs of low blood sugar, such as feeling shaky, sweaty, hungry, or dizzy. If you notice these symptoms frequently, speak to your doctor.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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