Skip to main content

Can I take Aspirin and Vitamin d2 together?

Drug interaction guide

There are no known significant interactions between aspirin and vitamin D2 (ergocalciferol). It is generally considered safe to take these two medications together.

Continue reading below

Why this happens

Aspirin and vitamin D2 are processed by the body through different pathways. Aspirin works by blocking certain enzymes to reduce pain and inflammation, while vitamin D2 is a fat-soluble vitamin that helps the body absorb calcium. They do not interfere with each other's absorption, metabolism, or effectiveness.

What you should do

You can continue to take both as prescribed or recommended. As with any supplement or medication, ensure you are taking the correct dose of vitamin D2 as advised by your healthcare professional, as excessively high doses of vitamin D can lead to high calcium levels.

Continue reading below

Important precautions

Asthma

Do not take this medicine if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening allergic reaction or asthma attack.

Pregnancy (third trimester)

You must not take aspirin during the last three months of pregnancy (from 28 weeks) as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.

Children and teenagers under 16 years old

Never give aspirin to children or teenagers under 16 unless specifically prescribed by a doctor. It can cause Reye’s syndrome, a rare but potentially fatal condition that causes serious liver and brain damage.

Food and drink warnings

Alcohol

Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.

Continue reading below

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.