Can I take Atorvastatin and Amlodipine together?

Why this happens

Amlodipine can slow down the process by which your liver breaks down atorvastatin (via an enzyme called CYP3A4). Because the atorvastatin is cleared more slowly, its levels in your body can rise.

What you should do

It is generally safe to take these together, but you should be aware of the signs of muscle problems. If you experience any unexplained muscle pain, tenderness, or weakness—especially if you also have a fever or feel generally unwell—contact your doctor. Your doctor may choose to limit your atorvastatin dose to a maximum of 20mg or 40mg if you are also taking amlodipine, though many patients tolerate higher doses without issues.

Important precautions

Pregnancy

You must not take this medicine if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking it.

Muscle pain or weakness

Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to serious kidney problems.

Grapefruit juice consumption

Avoid drinking large amounts of grapefruit juice. It can significantly increase the levels of these medicines in your blood, making side effects much more likely.

Food and drink warnings

Grapefruit and grapefruit juice

Grapefruit can increase the amount of these medicines in your blood, which makes side effects more likely. For atorvastatin, this can increase the risk of muscle damage. For amlodipine, it can cause your blood pressure to drop too low. You should avoid drinking large amounts of grapefruit juice or eating grapefruit while taking these medicines.

Alcohol

Drinking large amounts of alcohol while taking atorvastatin can increase your risk of liver problems. It is best to keep your alcohol intake within the recommended limits (no more than 14 units per week).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.