Can I take Berberine and Vitamin b12 together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking berberine may lower the levels of Vitamin B12 in your body over time. This could potentially lead to a Vitamin B12 deficiency if you take berberine for a long period.
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Why this happens
Berberine can change the balance of bacteria in your gut and may interfere with the way your digestive system absorbs Vitamin B12 from food or supplements.
What you should do
Back to contentsIf you are taking berberine long-term, you should have your Vitamin B12 levels checked periodically by your doctor. You may need to take a B12 supplement or increase your intake of B12-rich foods. If you feel unusually tired, have a sore tongue, or feel 'pins and needles', speak to your GP.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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