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Can I take Bisoprolol and Lercanidipine together?

Drug interaction guide

Taking bisoprolol and lercanidipine together can cause your blood pressure to drop lower than if you took either medicine alone. It can also slow down your heart rate more than usual. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly.

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Why this happens

Both medicines work to lower blood pressure but in different ways: bisoprolol is a 'beta-blocker' that slows the heart, while lercanidipine is a 'calcium channel blocker' that widens blood vessels. When used together, their effects add up (an additive effect), which can significantly lower blood pressure and heart rate.

This combination is common and often prescribed by doctors to treat high blood pressure, but you should be monitored closely. When you first start taking them together, or if your dose is increased, take extra care when standing up. If you feel very dizzy, tired, or notice a very slow pulse, contact your doctor. Do not stop taking either medicine without medical advice.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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