Can I take Cannabis and Sertraline together?

Why this happens

Both substances affect brain chemicals. Sertraline increases serotonin levels, and cannabis may further influence this, potentially leading to an overload (serotonin syndrome). Furthermore, cannabis can slow down the liver enzymes (specifically CYP2C19) that break down sertraline, causing the medication to build up to higher-than-intended levels in your bloodstream.

What you should do

It is best to avoid using cannabis while taking sertraline. If you do choose to use it, do so with extreme caution, start with a very low amount, and ensure someone is with you. Seek medical help immediately if you experience a rapid heartbeat, severe shivering, or confusion. Discuss your use with your GP or pharmacist, as they may need to monitor your sertraline dose more closely.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.