Can I take Clarithromycin and Ibuprofen together?

Why this happens

Clarithromycin is an antibiotic and ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). They do not significantly interfere with how the body processes (metabolises) each other. The main concern is a 'pharmacodynamic' one, where both drugs have the potential to irritate the lining of the stomach or put slight stress on the kidneys, though this is rarely a problem for healthy individuals.

What you should do

It is generally safe to take these two medicines together. To protect your stomach, try to take both the clarithromycin and the ibuprofen with food or a milky drink. If you develop severe stomach pain, persistent vomiting, or if you feel very dehydrated, stop taking the ibuprofen and speak to your doctor or pharmacist. Always complete the full course of your antibiotic.

Important precautions

Heart rhythm disorders (Long QT syndrome)

Clarithromycin can cause serious heart rhythm problems. You must not take it if you have a history of 'Long QT syndrome' or are taking other medicines that affect your heart rate.

Asthma

Do not take ibuprofen if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Stomach ulcers or kidney problems

Avoid ibuprofen if you have ever had a stomach ulcer, perforation, or bleeding, or if you have severe kidney disease, as it can cause serious internal bleeding or kidney failure.

Food and drink warnings

Alcohol

While there is no direct interaction, both clarithromycin and alcohol can cause side effects like nausea, dizziness, or stomach upset. It is generally best to avoid alcohol until you have finished your course and feel better.

Food (General)

You should ideally take ibuprofen with food or a glass of milk to reduce the risk of indigestion or stomach irritation.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.