Can I take Devil's claw and Turmeric with black pepper together?

Why this happens

Both devil's claw and turmeric have mild 'blood-thinning' properties (antiplatelet effects), which can have an additive effect when combined. They also both possess glucose-lowering properties. The black pepper (piperine) in the turmeric supplement is designed to significantly increase the absorption of turmeric, which may also inadvertently increase the absorption or slow the breakdown of devil's claw in the liver.

What you should do

Use this combination with caution. If you notice unusual bruising, nosebleeds, or bleeding gums, stop taking them and consult your doctor. If you have diabetes, monitor your blood sugar levels closely. It is best to take these supplements with food to protect your stomach. Always inform your doctor or pharmacist before starting these supplements if you are taking prescribed blood thinners (like warfarin) or stomach acid reducers.

Important precautions

Gallstones or bile duct obstruction

Both medicines stimulate bile production. If you have gallstones or a blocked bile duct, this can cause a painful gallbladder attack or worsen the blockage.

Stomach or duodenal ulcers

Devil's claw increases the production of stomach acid, which can severely irritate or worsen existing stomach or intestinal ulcers.

Blood-thinning medications (e.g., warfarin, clopidogrel)

Both supplements can increase the risk of bruising and bleeding if taken with anticoagulant or antiplatelet medicines. Black pepper also significantly increases the absorption of many drugs, potentially leading to toxic levels.

Diabetes

Both supplements can lower blood sugar levels. If you take insulin or oral diabetes medication, using these supplements may increase the risk of hypoglycaemia (low blood sugar).

Heart rhythm disorders (arrhythmias)

Devil's claw can affect heart rate and blood pressure; use with caution if you have a heart condition or take blood pressure medication.

Food and drink warnings

Alcohol

Devil's claw can increase the production of stomach acid. Combining it with alcohol, which also irritates the stomach lining, may increase the risk of stomach upset or gastric ulcers.

It is best to avoid or strictly limit alcohol when taking turmeric supplements. Both alcohol and high doses of turmeric can put strain on the liver; combining them may increase the risk of liver irritation or damage.

Grapefruit juice

Grapefruit juice should be avoided or limited. Black pepper contains piperine, which, like grapefruit, interferes with enzymes in the liver and gut that break down medicines. Combining them may significantly alter how your body processes other medications you may be taking.

Caffeine

Piperine (found in black pepper) can slow down the rate at which your body rids itself of caffeine. This may increase the effects of caffeine, leading to jitters, heart palpitations, or insomnia.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.