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Can I take Evening primrose oil and Vitamin d3 together?

Drug interaction guide

There are no known significant interactions between evening primrose oil and vitamin D3. It is generally considered safe to take these two supplements together.

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Why this happens

Evening primrose oil is a source of omega-6 fatty acids (gamma-linolenic acid), while vitamin D3 is a fat-soluble vitamin. Because vitamin D3 requires fat to be absorbed properly by the body, taking it alongside a fatty acid supplement like evening primrose oil may actually help your body absorb the vitamin D more effectively.

You can continue taking both supplements as directed. For the best results, take them with a meal that contains some healthy fats to further aid the absorption of vitamin D3. Always inform your doctor or pharmacist about all the supplements you are taking.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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