Can I take Evolocumab and Furosemide together?

Why this happens

Evolocumab is a monoclonal antibody that helps the liver remove cholesterol from the blood. Furosemide is a diuretic (water tablet) that helps the kidneys remove excess salt and water. These medicines are processed by different pathways in the body and do not overlap in their actions.

What you should do

You can safely take these two medicines together as prescribed by your doctor. No special precautions or dose changes are needed. Always inform your healthcare provider of all medications you are taking, including over-the-counter supplements.

Important precautions

Dehydration and low blood pressure

Furosemide is a potent diuretic. You must not take it if you are already severely dehydrated or cannot pass urine. It can cause a rapid drop in blood pressure and salt levels, especially if you are also taking other blood pressure medicines.

Gout

Furosemide can increase the levels of uric acid in your blood, which may trigger a painful gout attack or make existing gout worse.

Latex allergy - evolocumab

The needle cover of the pre-filled syringe/pen contains dry natural rubber (a derivative of latex), which may cause severe allergic reactions in people with a sensitive latex allergy.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking furosemide. Both alcohol and furosemide can lower your blood pressure and have a diuretic effect (making you pee more). Combining them increases the risk of dizziness, lightheadedness, or fainting, especially when standing up. It can also lead to dehydration.

It is best to avoid or strictly limit alcohol while taking evolocumab. Combining alcohol with cholesterol-lowering treatments can increase the risk of liver strain or damage.

Liquorice (Natural) / Liquorice Root

Avoid eating large amounts of natural liquorice or taking liquorice root supplements. Natural liquorice can cause the body to lose potassium and retain salt, which opposes the action of furosemide and can lead to dangerously low potassium levels.

Caffeine (Coffee, Tea, Energy Drinks)

Limit your intake of caffeine. Caffeine is a mild diuretic and can increase the water-loss effect of furosemide, potentially increasing the risk of dehydration or electrolyte imbalances.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.