Can I take Ezetimibe and Magnesium together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking magnesium (specifically as an antacid) at the same time as ezetimibe may slightly lower the amount of ezetimibe your body absorbs. However, this effect is very small and is not expected to change how well your cholesterol is managed.
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Why this happens
Magnesium-containing antacids can physically bind to ezetimibe in the digestive tract or change the acidity of the stomach, which slightly reduces the rate at which the medicine enters the bloodstream.
What you should do
You can take these together, but to be safe, you may wish to separate the doses by 2 to 4 hours. If you are taking magnesium as a daily supplement rather than an antacid, the interaction is even less likely to be significant. Continue to have your cholesterol levels monitored by your doctor as usual.
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Important precautions
Liver disease
You must not take ezetimibe if you have moderate or severe liver disease, as it can worsen your condition. Contact your doctor immediately if you develop yellowing of the skin or eyes.
Severe kidney impairment
If you have severe kidney disease, you must avoid magnesium supplements unless specifically directed by a specialist. Your kidneys may not be able to remove excess magnesium, leading to dangerously high levels in the blood.
Food and drink warnings
Dairy products and calcium-rich foods
High doses of calcium from dairy or supplements can compete with magnesium for absorption. If you are taking large amounts of both, it is best to space them at least 2 hours apart.
Alcohol
Excessive alcohol consumption can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective over time.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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