Can I take Fluoxetine and Venlafaxine together?

Why this happens

Both fluoxetine and venlafaxine work by increasing serotonin levels in the brain. When used together, their effects add up (an additive effect). Additionally, fluoxetine can slow down the way your liver breaks down venlafaxine, causing the levels of venlafaxine in your blood to rise even higher.

What you should do

You should not take these two medicines together unless specifically instructed and closely monitored by a specialist. If you are already taking both and feel unwell, seek medical help immediately. If your doctor is switching you from one to the other, they will usually advise a 'washout' period (a gap of a few weeks) because fluoxetine stays in your system for a long time.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.