Can I take Hydroxycarbamide and Naproxen together?

Why this happens

This is a 'double-hit' interaction. Firstly, both drugs have 'myelosuppressive' effects (they slow down blood cell production in the bone marrow). Secondly, naproxen can interfere with how the kidneys filter waste; since hydroxycarbamide is mainly removed from the body by the kidneys, any reduction in kidney function can cause hydroxycarbamide to build up to dangerous levels.

What you should do

You should speak to your doctor before taking these two medicines together. Your doctor may suggest an alternative painkiller, such as paracetamol, which does not affect the kidneys in the same way. If you must take both, your doctor will likely want to perform more frequent blood tests to monitor your kidney function and your blood cell counts. Seek medical help immediately if you notice unusual bruising, bleeding, a sore throat, or a fever.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.