Can I take Ibuprofen and Diclofenac together?

Why this happens

Both ibuprofen and diclofenac are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). They work by blocking enzymes (COX-1 and COX-2) that produce chemicals called prostaglandins. While prostaglandins cause pain and inflammation, they also protect the lining of your stomach and keep your kidneys working properly. By blocking these enzymes twice over, you lose that vital protection, leading to a much higher risk of damage to your digestive system and kidneys.

What you should do

Do not take these two medicines together. If you find that one is not providing enough pain relief, speak to your doctor or pharmacist. They may suggest a different type of painkiller that is safe to take alongside an NSAID, such as paracetamol. If you have already taken both and experience severe stomach pain, black tarry stools, or vomit that looks like coffee grounds, seek medical help immediately.

Important precautions

Asthma

Do not take these medicines if you have asthma and have ever experienced wheezing, breathlessness, or a skin rash after taking aspirin or other NSAIDs, as they can trigger a life-threatening asthma attack.

Stomach ulcers or bleeding

Avoid these medicines if you have a history of stomach ulcers or gastrointestinal bleeding. They significantly increase the risk of serious stomach irritation and internal bleeding.

Pregnancy (Third Trimester)

Do not take these medicines if you are more than 28 weeks pregnant. They can cause serious heart and kidney problems in the unborn baby and may lead to complications during delivery.

Food and drink warnings

Alcohol

Drinking alcohol while taking NSAIDs like diclofenac or ibuprofen can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it entirely if you have a history of stomach issues.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.