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Can I take Ibuprofen gel 10% and Naproxen bp together?

Drug interaction guide

Using ibuprofen gel alongside naproxen tablets increases your risk of side effects, such as stomach irritation, indigestion, or even stomach ulcers. It can also increase the strain on your kidneys.

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Why this happens

Both ibuprofen and naproxen belong to the same family of medicines called NSAIDs (non-steroidal anti-inflammatory drugs). Even though the gel is applied to the skin, some of it is absorbed into your bloodstream. Taking two medicines from the same family 'stacks' the effect, making side effects more likely without necessarily providing better pain relief.

What you should do

You should generally avoid using ibuprofen gel if you are already taking naproxen tablets unless your doctor has specifically told you to do so. If you need extra pain relief, speak to a pharmacist or doctor about safer alternatives, such as paracetamol.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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